Gompertz model-based tumor radiotherapy analysis and simulation(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2018年第1期
- Page:
- 5-8
- Research Field:
- 医学放射物理
- Publishing date:
Info
- Title:
- Gompertz model-based tumor radiotherapy analysis and simulation
- Author(s):
- HONG Wensong; ZHANG Li; CHEN Bingfeng; LI Zhen; HUANG Kailing
- Department of Radiotherapy, Guangdong Second Provincial General Hospital, Guangzhou 510317, China
- Keywords:
- ; Keywords: Gompertz model; fractional radiotherapy model; radiotherapy optimization; tumor
- PACS:
- R730.1
- DOI:
- DOI:10.3969/j.issn.1005-202X.2018.01.002
- Abstract:
- Abstract: Objective To discuss the optimization of personalized radiotherapy based on the fractional radiotherapy mathematical model derived from classical Gompertz mathematical model of tumor growth. Methods The classical Gompertz model of tumor growth was analyzed, and the proper parameters were selected to establish a fractional radiotherapy model. With the computer simulation, we discussed the effects of single dose, fractional dose and α/β value on the therapeutic effect. Results The whole model run stably and output stable results. The simulation results revealed that both the radiotherapy dose and α/β value had remarkable effects on the therapeutic effect of radiotherapy, which indicated that lots of accurate data were necessary for the optimization of personalized radiotherapy. Conclusion To some extent, the Gompertz model-based radiotherapy model can simulate the therapeutic effect of radiotherapy as well as provide some theoretical instructions for the optimization of personalized radiotherapy.
Last Update: 2018-01-25