Turning point during the intracerebral hemorrhage of rabbit monitored with magnetic induction method(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2017年第11期
- Page:
- 1150-1155
- Research Field:
- 医学信号处理与医学仪器
- Publishing date:
Info
- Title:
- Turning point during the intracerebral hemorrhage of rabbit monitored with magnetic induction method
- Author(s):
- DUAN Haijun1; JIN Gui2; BAI Zelin2; ZHUANG Wei2; MA Ke2
- 1. Department of Neurosurgery, First Affiliated Hospital, Third Military Medical University, Chongqing 400038, China; 2. School of Biomedical Engineering, Third Military Medical University, Chongqing 400038, China
- Keywords:
- ; Keywords: magnetic inductive phase shift; intracranial hemorrhage; cerebrospinal fluid; coil
- PACS:
- R318
- DOI:
- DOI:10.3969/j.issn.1005-202X.2017.11.013
- Abstract:
- Abstract: Intracranial hemorrhage (ICH) is associated with high mortality and disability rate. Nowadays, only CT and MRI can be used for the detection of bleeding but they fail to monitor the change of ICH timely and can’t be applied for pre-hospital care. Magnetic inductive phase shift (MIPS) using alternating magnetic field to measure the conductivity is a non-invasive and non-contact method, which has been applied in the commercial measurement and food detection. Herein, a double-end exciting coil was developed to detect the MIPS after ICH in rabbit brain for evaluating the changes of bleed volume, and the MIPS parameters were phase difference. In blood injection group, ICH was simulated by injecting 3 mL of autologous blood into the rabbit brain at a constant speed of 3 mL/h, and MIPS parameters were measured synchronously. The MIPS parameters measured before 1 h of blood injection were taken as the controls. Moreover, MRI scan group was established by performing the same blood injection procedure and scanning rabbit brain with MRI synchronously. The results showed that the MIPS value initially declined and then increased with the increasing blood injection volume, showing a turning point. Statistical differences were found between blood injection group and controls group (P<0.05). The MRI scanned images indicated that the average reduced volume of cerebrospinal fluid (CSF) in the rabbit brain after blood injection was approximately equal to the average injection volume that corresponds to the turning point of the MIPS. Thus, we conclude that CSF is already exhausted and the compensatory stage has already ended when the MIPS turning point occurs. MIPS method has the potential to detect the CSF compensation end after ICH in a non-contact and non-invasive manner, warning the intracranial hypertension caused by ICH.
Last Update: 2017-11-23