Advances in application of molecular nuclear medicine in chimeric antigen receptor T cell immunotherapy(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2023年第9期
- Page:
- 1057-1063
- Research Field:
- 医学放射物理
- Publishing date:
Info
- Title:
- Advances in application of molecular nuclear medicine in chimeric antigen receptor T cell immunotherapy
- Author(s):
- HUANG Wenpeng; YANG Qi; CHEN Zhao; QIU Yongkang; SONG Lele; FAN Yan; KANG Lei
- Department of Nuclear Medicine, Peking University First Hospital, Beijing 100034, China
- Keywords:
- Keywords: molecular nuclear medicine immunotherapy immunoimaging chimeric antigen receptor review
- PACS:
- R392；R811.1
- DOI:
- DOI:10.3969/j.issn.1005-202X.2023.09.001
- Abstract:
- Abstract: Chimeric antigen receptor T cell (CAR-T) therapy as a novel and precision-targeted immunotherapy has revolutionized the treatment of hematologic malignancies. Molecular nuclear medicine technologies such as radionuclide-based PET and SPECT have the unique advantages of non-invasive, long-term dynamic, real-time monitoring of molecular targets at the in vivo level, which are conducive to optimize the timing and dose of CAR-T cell infusion and avoid potential biotoxicity, and play an important role in guiding the development of CAR-T therapy. A review on the application of radionuclide-based molecular nuclear medicine in the monitoring and efficacy assessment of CAR-T therapy is provided. The clinical application of some promising molecular probes helps to monitor CAR-T cell activity, biodistribution and delivery to targeted tumor sites.
Last Update: 2023-09-26