Abstract

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Title:: Clinical application of 3D printed bolus for nasal natural killer/T-cell lymphoma in radiotherapy

Author(s):: LI Jin; HUANG Yusheng; YANG Zhenzhou; HUANG Shunping; Department of Oncology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 401336, China

Keywords:: Keywords: nasal natural killer/T-cell lymphoma bolus 3D printing technology radiotherapy

Abstract:: Abstract: Objective To prepare a personalized bolus for patients with nasal natural killer (NT)/T-cell lymphoma using 3D printing technology, and to study the dosimetric effect of 3D printed bolus used for nasal NK/Tcell lymphoma in radiotherapy planning. Methods Ten patients with early nasal NK/T-cell lymphoma were enrolled in the study. CT images without bolus (CTno-bolus) and with 3D printed bolus (CTbolus) of each patient were acquired for treatment planning. The prescription dose of planning target volume (PTV) was 50 Gy/25 fractions. The dosimetric differences of PTV and organs-at-risk between two kinds of plans (Planbolus vs Planno-bolus) were evaluated using dose-volume histograms. Results The 3D printed bolus which closely fitted the body surface improved the uniformity and conformity of PTV. The doses to lens, optic nerves and parotids in Planbolus were all lower than those in Planno-bolus (P<0.05). Conclusion 3D printed bolus is worth to be promoted for clinic use for it can effectively improve the dose distribution of nasal NK/T-cell lymphoma target area adjacent to the epidermis.