Diagnostic value of the maximum Youngs modulus of real-time shear wave elastography in BRAF V600E gene mutation in papillary thyroid carcinoma(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2020年第8期
- Page:
- 1040-1044
- Research Field:
- 医学影像物理
- Publishing date:
Info
- Title:
- Diagnostic value of the maximum Youngs modulus of real-time shear wave elastography in BRAF V600E gene mutation in papillary thyroid carcinoma
- Author(s):
- WANG Nan; LIU Hui; ZHU Chengtao; ZHU Ying
- Department of Ultrasound Medicine, Suqian First Hospital, Suqian 223800, China
- Keywords:
- Keywords: real-time shear wave imaging papillary thyroid carcinoma V600E gene maximum Youngs modulus
- PACS:
- R581
- DOI:
- DOI:10.3969/j.issn.1005-202X.2020.08.019
- Abstract:
- Abstract: Objective To investigate the value of the maximum Youngs modulus (Emax) of real-time shear wave elastography (SWE) in the diagnosis of the mutation of BRAF V600E gene in papillary thyroid carcinoma (PTC). Methods The clinical and ultrasonographic data of 124 nodules from 110 PTC patients who were admitted to Suqian First Hospital from January 2018 to June 2019 were analyzed retrospectively. The patients were diagnosed with PTC by pathological examination and underwent BRAF V600E gene test and SWE, having complete clinical data. The SWE results of V600E gene mutant PTC were compared with those of wild-type PTC, and then the ROC curve of Emax was plotted for analyzing the diagnostic efficacy of Emax for the BRAF V600E gene mutation in PTC patients. Results BRAF gene test results revealed that out of 124 PTC nodules, 37 were V600E wild-type and 87 were V600E mutant. The SWE images of wild-type PTC nodules were mostly blue, while the SWE images of mutant PTC nodules were mainly characterized by red and orange. The Emax, Emean and Eratio of the mutant PTC nodules were significantly higher than those of wild-type PTC nodules, with statistical differences (P<0.05). The ROC curve analysis showed that the diagnosis of V600E mutation by Emax had an AUC=0.846>0.5 (95%CI: from 0.808 to 0.885, P<0.01). Cut-off value was 43.65 kPa, and at this time, the sensitivity and the specificity were 91.45% and 68.23%. With Emax≥43.65 kPa as the critical value, 124 nodules were diagnosed, and the diagnostic results by SWE showed that there were V600E gene mutants in 90 PCT nodules and wild-type in 34 PCT nodules, with a diagnostic?ccuracy of 86.29%. There was a significant consistency between SWE diagnosis and genetic test results (Kappa=0.665, P<0.01). Conclusion The SWE imaging features of BRAF V600E gene mutant PTC are significantly different from those of wild-type. The Emax of real-time SWE can achieve a high accuracy and sensitivity in the diagnosis of V600E gene mutation in PTC nodules, with significant diagnostic value and worthy of clinical application.
Last Update: 2020-08-27