Abstract

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Title:: Therapeutic effects of graphene thermal therapy for benign thyroid nodules

Author(s):: REN Huiya1; GAO Hongbo2; LI Yueqiu3; LI Aihong1; ZHANG Guilin1; LI Jinghua4; 1. Department of Endocrinology, Baoding No.1 Hospital, Baoding 071000, China; 2. Department of Cardiology, Baoding No.1 Central Hospital, Baoding 071000, China; 3. Grahope New Materials Technologies Inc., Shenzhen 518057, China; 4. Department of Preventive Medicine, School of Traditional Chinese Medicine, Chengde Medical College, Chengde 067000, China

Keywords:: ; Keywords: thyroid nodule; grapheme; thermal therapy; maximum diameter; maximum cross-sectional area

Abstract:: Abstract: Objective To explore the responses of benign thyroid nodules to graphene thermal therapy. Methods A total of 97 patients with benign thyroid nodules were enrolled in this study and then randomly divided into control group (n=47) and treatment group (n=50). Control group did not receive any intervention measure, while treatment group received 4 courses (120 days) of graphene neck protection bandage treatment. The maximum diameter and maximum cross-sectional area of the thyroid nodules before and after treatment in both groups were measured with ultrasound. Thyroid functions (FT3, FT4 and thyroid stimulating hormone) in both groups before and after treatment were detected by direct chemiluminescence. Results The maximum diameter and maximum cross-sectional area of the thyroid nodules before and after treatment showed no obvious changes in control group (P>0.05). However, the maximum diameter and maximum cross-sectional area of the thyroid nodules in treatment group were reduced by (0.17±0.13) cm and (0.41±0.45) cm2, respectively (P<0.05). The hyroid functions remained stable in both groups before and after treatment (P>0.05). Conclusion Graphene thermal therapy which can reduce the maximum diameter and maximum cross-sectional area of benign thyroid nodules and has no significant effects on the thyroid functions is worthy of clinical application.