Abstract

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Title:: Dosimetric comparison between radical intensity-modulated radiotherapy and tomotherapy in 20 patients with middle thoracic esophageal cancer

Author(s):: TANG Kewei; ZHAO Biao; ZHAO Yutao; HE Liqiu; AN Yijun; YANG Yi; Radiotherapy Center, the Third Affiliated Hospital of Kunming Medical University & Yunnan Cancer Center, Kunming 650118, China

Keywords:: ; Keywords: esophageal cancer; radical radiotherapy; intensity-modulated radiotherapy; tomotherapy; dosimetry

Abstract:: Abstract: Objective To compare the dosimetric characteristics of fixed-field static intensity-modulated radiotherapy (IMRT) and tomotherapy (TOMO) of middle thoracic esophageal cancer for guiding the selection of clinical treatment options. Methods IMRT and TOMO techniques were applied separately. The prescription dose was 54 Gy/30 F for planning target volume (PTV) and 66 Gy/30 F for planning gross target volume (PGTV). The dosimetric differences in the target areas were compared between two treatment options. Results The maximum dose (D2), median dose (D50) and homogeneity index of PTV were lower in TOMO group as compared with IMRT group, while the minimum dose (D98) and conformity index in TOMO group were significantly higher than those in IMRT group (all P<0.05). Except for D98, no statistical differences were found in PGTV between the two plans (P>0.05), and the remaining indicators of PGTV were consistent with PTV, with statistical significance (P<0.05). Conclusion The target dose distribution and conformality of TOMO plan in radical treatment of middle thoracic esophageal cancer are obviously superior to those of IMRT plan, and the ranking indexes of organs-at-risk of the former are also superior to the latter.