Abstract

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Title:: Effect of simultaneous integrated boost IMRT on quality of life in patients with advanced nasopharyngeal carcinoma

Author(s):: LIU Bin1; CHEN Zi1; HU Zhihui2; LI Yan3; CHEN Kun1; 1. Department of Otolaryngology, Head and Neck Surgery, Shijiazhuang People’s Hospital, Shijiazhuang 050000, China; 2. Department of Oncology, Shijiazhuang People’s Hospital, Shijiazhuang 050000, China; 3. Department of Orthopedics, the Third Hospital of Shijiazhuang, Shijiazhuang 050011, China

Keywords:: simultaneous integrated boost intensity-modulated radiotherapy; advanced nasopharyngeal carcinoma; quality of life

Abstract:: Objective To explore and analyze the clinical efficacy of simultaneous integrated boost intensity-modulated radiotherapy (IMRT) and its effect on quality of life in advanced nasopharyngeal carcinoma (NPC) patients. Methods A retrospective analysis was conducted on 62 patients with advanced NPC. Patients were divided into trial group (n=31, simultaneous integrated boost IMRT + chemotherapy) and control group (n=31, conventional IMRT + chemotherapy) according to different treatment regimens. The two groups were compared for objective response rate, disease control rate, recurrence and metastasis rate, long-term survival rate, quality of life score, and incidence of adverse reactions. Results Compared with control group, trial group resulted in higher objective response rate, disease control rate and long-termsurvival rate, while lower recurrence and metastasis rate, post-therapy quality of life score and incidence of adverse reactions (all P<0.05). Conclusion Patients with advanced NPC show remarkable response to simultaneous integrated boost IMRT which can reduce recurrence and metastasis rate, prolong survival cycle, improve quality of life, and lower incidence of adverse reactions.