Abstract

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Title:: Non-invasive detection of rat skin scars using terahertz time-domain spectroscopy technology

Author(s):: MUREZIYA Yimingjiang1; GENG Shaohui1; GUAN Yiwei2; SHEN Chunli3; WEN Jingqi4; HUANG Guangrui1; 1. School of Life Sciences, Beijing University of Chinese Medicine, Beijing 102446, China 2. School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China 3. School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing 100029, China 4. School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China

Keywords:: Keywords: skin scar terahertz time-domain spectroscopy principal component analysis

Abstract:: Abstract: Objective To explore the difference in terahertz signal characteristics between rat skin scar and normal skin using terahertz time-domain spectroscopy technology, thereby providing a novel non-invasive detection technique for the pathological examination of skin scars. Methods A rat model of whole-layer skin defect was prepared, and a reflectance terahertz time-domain spectroscopy system was used to obtain the terahertz signal maps of normal skin and scarred area. Results The terahertz signals of normal skin showed two obvious reflection time-domain signal peaks, and the characteristics of the reflection peaks at different reflection points were relatively regular. The terahertz signals of skin scar also had two obvious reflection time-domain signal peaks, but the highest peak was lower than that of normal skin. In addition, principal component analysis revealed that skin scar signals and normal skin signals were clustered together separately. The terahertz signal at different sites differed significantly (P<0.05). Conclusion Terahertz time-domain spectroscopy technology can be applied to the non-invasive detection of skin scarring, exhibiting a good application prospect in biomedicine.