Abstract

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Title:: Fluorescent probes and imaging techniques for deep-tissue optical imaging: a review

Author(s):: GAO Yuxiang1; GUO Le2; LI Hui2; ZHANG Xueliang1; ALIFU Nuernisha1; 1. School of Medical Engineering and Technology, Xinjiang Medical University, Urumqi 830011, China 2. School of Public Health, Xinjiang Medical University, Urumqi 830011, China

Keywords:: Keywords: optical imaging near-infrared II region bioluminescence chemiluminescence adaptive optics review

Abstract:: The research advancements in probes for deep-tissue imaging and adaptive optical imaging technologies are summarized, aiming to offer a new perspective for life science and interdisciplinary research. The review firstly gives an introduction on the probes emitting in the near-infrared-II region, including fluorescence, bioluminescence, chemiluminescence, and persistent luminescence, and then elaborates direct sensing methods for rapid measurement and correction of wavefront distortions, as well as indirect sensing methods for correcting complex optical aberrations. The continuous updating of the above techniques and methods has enabled optical imaging to successfully penetrate deeper tissues with a remarkable reduction of background noise for higher image quality.