Therapeutic effect of 131iodine on Graves hyperthyroidism with thyroid nodules(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2023年第11期
- Page:
- 1332-1335
- Research Field:
- 医学放射物理
- Publishing date:
Info
- Title:
- Therapeutic effect of 131iodine on Graves hyperthyroidism with thyroid nodules
- Author(s):
- ZHANG Xiaohui1; CAO Xiandong2; SHAO Dan3
- 1. Department of Nuclear Medicine, the Third People′s Hospital of Shenzhen, Shenzhen 518100, China 2. Department of Statistics, the Third People′s Hospital of Shenzhen, Shenzhen 518100, China 3. Department of Nuclear Medicine, Guangdong Provincial Peoples Hospital, Guangzhou 510000, China
- Keywords:
- Keywords: Graves disease 131iodine inner radiation therapy thyroid nodule
- PACS:
- R817.8
- DOI:
- DOI:10.3969/j.issn.1005-202X.2023.11.003
- Abstract:
- Abstract: Objective To observe the changes in the size of thyroid nodules after 131iodine (131I) therapy in patients with Graves hyperthyroidism (GH) and thyroid nodules for exploring the efficacy of 131I for thyroid nodules while treating GH. Methods A retrospective analysis was conducted on 106 patients with GH and thyroid nodules receiving individualized 131I therapy. A total of 193 nodules were identified and categorized into 3 groups according to their size (group A: nodule diameter ≤ 5 mm, group B: 5 mm < nodule diameter ≤ 10 mm, group C: nodule diameter >10 mm). The changes in nodule size before and after 131I therapy were analyzed in the 3 groups to analyze the therapeutic effects of 131I on nodules of different sizes. Multiple linear regression analysis was used to identify factors related to therapeutic effects. Results In group A, there were 59 thyroid nodules, of which 83.33% disappeared after 131I therapy, 7.41% decreased in size, and 9.26% remained unchanged or enlarged, with an overall response rate of 90.74%. In group B, there were 108 thyroid nodules, with 61.82% disappearing after 131I therapy, 21.82% decreasing in size, and 16.36% remaining unchanged or enlarged, and the overall response rate was 83.64%. There were 26 nodules in group C, with 31.58% disappearing after 131I therapy, 31.58% decreasing in size, and 36.84% remaining unchanged or enlarged, and the overall response rate was 63.16%. The nodule size in the 3 groups changed differently (P<0.05). Nodule size and age were found to be correlated with therapeutic effect, while thyroid weight, individualized dose of 131I, gender, TT3, TT4, TSH, 2-h iodine uptake rate, and 24-h iodine uptake rate had no correlation with therapeutic effect. Conclusion 131I therapy is effective for GH and benign small nodules in the thyroid, especially for nodules smaller than 10 mm.
Last Update: 2023-11-24