Abstract

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Title:: Bioelectromagnetic dosimetric study of human blood-brain barrier opening induced by electromagnetic pulse

Author(s):: LIN Jiajin; ZHOU Yan; DING Guirong; LI Jing; Department of Radiation Biology, Faculty of Preventive Medicine, Air Force Medical University/Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, Xian 710032, China

Keywords:: Keywords: electromagnetic pulse blood-brain barrier clinical application dose biosafety

Abstract:: Abstract: Objective To analyze the bioelectromagnetic dose of human blood-brain barrier opening induced by electromagnetic pulse. Methods A typical exposure platform was used to establish an environment for human brain dosimetric study. The bioelectromagnetic dose was evaluated with electromagnetic simulation method using a 3D digital human model. Results The electric field at the centre of the head reached a peak of 1.49 kV/m, and there was a decrease of 41.6 dB from the excitation field. The maximum electric field amplitude on the surface of the nose tip was 1 795 kV/m. The head had an average absorption rate of 4.16×10-8 J/kg under one pulse, while under extreme conditions with a repetition frequency of 1 000 s-1, the average specific absorption rate of the head was 4.16×10-5 W/kg. Conclusion Local high-intensity electric fields pose significant safety risks in clinical application, and it is necessary to study the means of inhibiting local high-intensity electric field in combination with the dose-effect relationship of blood-brain barrier opening. The human brain bioelectromagnetic doses provided by the study can be used to evaluate the clinical efficacy.