Effect of rivaroxaban combined with blood circulation driven pump on prevention and prognosis of deep vein thrombosis after surgery for spinal tuberculosis(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2023年第8期
- Page:
- 1022-1025
- Research Field:
- 医学生物物理
- Publishing date:
Info
- Title:
- Effect of rivaroxaban combined with blood circulation driven pump on prevention and prognosis of deep vein thrombosis after surgery for spinal tuberculosis
- Author(s):
- LIN Jie; WU Xiaoying; DING Liqi
- Shanghai Pulmonary Hospital Affiliated to Tongji University/Shanghai Red Cross Pulmonary Hospital/Shanghai Hospital of Prevention and Treatment for Occupational Disease, Shanghai 200433, China
- Keywords:
- Keywords: spinal tuberculosis blood circulation driven pump rivaroxaban deep vein thrombosis coagulation function blood viscosity adverse reaction
- PACS:
- R619.2
- DOI:
- DOI:10.3969/j.issn.1005-202X.2023.08.016
- Abstract:
- Abstract: Objective To investigate the effect of the combined treatment of rivaroxaban and blood circulation driven pump on prevention and prognosis of deep vein thrombosis after surgery in patients with spinal tuberculosis. Methods Ninety cases of spinal tuberculosis were enrolled and randomly divided into 2 groups, with 45 cases in each group. All patients received surgery by the same surgeon. Rivaroxaban was used in control group for anticoagulant therapy, while rivaroxaban combined with blood circulation driven pump was adopted in observation group. The incidence of pulmonary embolism and deep vein thrombosis were compared between 2 groups and the changes of hemorheological indexes [plasma viscosity, low-shear and high-shear blood viscosities, and fibrinogen], prothrombin time and D-dimer level before and after treatment, and adverse reactions were recorded. Results The incidences of pulmonary embolism and deep vein thrombosis in observation group were 2.22% and 4.44%, lower than those in control group (P<0.05). After treatment, the plasma viscosity, low-shear and high-shear blood viscosities, fibrinogen and D-dimer level in both groups decreased, and the indexes were lower in observation group than control group (P<0.05). The incidence of adverse reactions in observation group was lower than that in control group (6.67% vs 24.44%, P<0.05). Conclusion The combined treatment of rivaroxaban and blood circulation driven pump in patients with spinal tuberculosis can effectively improve the blood coagulation function, reduce blood viscosity, and prevent postoperative pulmonary embolism, deep venous thrombosis and adverse reactions.
Last Update: 2023-09-06