Effects of optimizing target volume on oral mucosal reaction and salivary gland function in oropharyngeal cancer patients undergoing intensity-modulated radiotherapy(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2024年第2期
- Page:
- 145-150
- Research Field:
- 医学放射物理
- Publishing date:
Info
- Title:
- Effects of optimizing target volume on oral mucosal reaction and salivary gland function in oropharyngeal cancer patients undergoing intensity-modulated radiotherapy
- Author(s):
- WANG Runkun; LU Hanqiang; HUANG Qiusheng
- Department of Otolaryngology, Head and Neck Surgery, Affiliated Hospital of Jiangsu University, Zhenjiang 212000, China
- Keywords:
- Keywords: oropharyngeal cancer intensity-modulated radiotherapy target volume optimization oral mucosal reaction salivary gland function
- PACS:
- R739.8；R811.1
- DOI:
- DOI:10.3969/j.issn.1005-202X.2024.02.003
- Abstract:
- Abstract: Objective To analyze the effects of target volume optimization on oral mucosal reaction and salivary gland function in oropharyngeal cancer patients receiving intensity-modulated radiotherapy (IMRT). Methods A total of 120 patients with oropharyngeal cancer admitted to Affiliated Hospital of Jiangsu University from April 2020 to August 2022 were selected and randomly grouped into control group (n=60, conventional IMRT) and treatment group (n=60, cervical region II and the oral target region were optimized during IMRT). The therapeutic efficacy, parotid gland dose, incidence of acute oral mucosal reaction, dry mouth and oral pain at 3 months after IMRT were compared between two groups. The resting-state apparent diffusion coefficient (ADC) values of parotid and submandibular glands at different time points (before radiotherapy, the 4th week of radiotherapy, the end of radiotherapy and 3 months after radiotherapy) were recorded. Results The difference in the objective reaction rate between two groups was trivial ［80.00% (48/60) vs 75.00% (45/60), P>0.05］. The mean dose (Dmean) and V34 of the unaffected parotid gland and the Dmean and V30 of the oral cavity in treatment group were lower than those in control group (P<0.05). The incidences of acute oral mucosal reaction, dry mouth and oral pain at 3 months after radiotherapy in treatment group were 41.67%, 50.00%, and 58.33%, lower than those in control group (75.00%, 78.33%, and 85.00%) (P<0.05). The resting-state ADC values of parotid and submandibular glands at the 4th week of radiotherapy, the end of radiotherapy, and 3 months after radiotherapy in both two groups were higher than those before radiotherapy (P<0.05). At the 4th week of radiotherapy, the end of radiotherapy, and 3 months after radiotherapy, the resting-state ADC values of parotid and submandibular glands in treatment group were lower than those in control group (P<0.05). Conclusion Optimizing target volume during oropharyngeal IMRT can effectively prevent the occurrence of radiation-induced mucositis, alleviate oral mucosal reaction, oral pain and dry mouth, reduce parotid gland dose, and diminish the effects of IMRT on salivary gland function in patients.
Last Update: 2024-02-27