Therapeutic effect of rTMS on post-stroke cognitive dysfunction: an analysis using functional MRI(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2023年第7期
- Page:
- 872-875
- Research Field:
- 医学影像物理
- Publishing date:
Info
- Title:
- Therapeutic effect of rTMS on post-stroke cognitive dysfunction: an analysis using functional MRI
- Author(s):
- LI Juan1; DONG Jianhua2; ZHANG Kun3
- 1. Department of Rehabilitation Medicine, Hohhot First Hospital, Hohhot 010000, China 2. Intensive Care Unit, Hohhot First Hospital, Hohhot 010000, China 3. Department of Medical Imaging, Hohhot First Hospital, Hohhot 010000, China
- Keywords:
- Keywords: stroke functional magnetic resonance repeated transcranial magnetic stimulation cognitive dysfunction regional homogeneity amplitude of low frequency fluctuation
- PACS:
- R49；R816.1
- DOI:
- DOI:10.3969/j.issn.1005-202X.2023.07.013
- Abstract:
- Abstract: Objective To analyze the therapeutic effects of repeated transcranial magnetic stimulation (rTMS) on post-stroke cognitive dysfunction using functional magnetic resonance imaging (fMRI). Methods The 86 enrolled patients with post-stroke cognitive dysfunction underwent rTMS and fMRI examination before and 4 weeks after treatment. The regional homogeneity (ReHo) and amplitude of low frequency fluctuation (ALFF) were compared before and after treatment Montreal cognitive assessment scale (MOCA) was used to evaluate the cognitive ability, and Barthel index to assess the activity of daily living. Results The treatment significantly reduced ReHo values in left superior frontal gyrus, right lobe, right supramarginal gyrus, left middle frontal gyrus, and right inferior frontal gyrus, but increased ReHo values in left middle temporal gyrus, right inferior temporal gyrus, left superior temporal gyrus, and right cerebellar hemisphere. Compared with that before treatment, ALFF was reduced at the right precentral gyrus in the classical and Slow-4 bands, but enhanced at the right cerebellar Crus 2 in the Slow-4 band and at left parietal-inferior margin gyrus in the Slow-5 band. After treatment, the patients cognition and activity of daily living improved, and MOCA score and Barthel index increased (P<0.05). Conclusion rTMS for patients with post-stroke cognitive dysfunction can improve their cognitive ability and activity of daily living by regulating the spontaneous neuronal activity in the brain areas, with the potential for clinical application.
Last Update: 2023-07-15