Effects of single-port thoracoscopic surgery on oxidative injury, peripheral blood NE, Cor and IMA in elderly patients with NSCLC(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2023年第9期
- Page:
- 1156-1160
- Research Field:
- 医学生物物理
- Publishing date:
Info
- Title:
- Effects of single-port thoracoscopic surgery on oxidative injury, peripheral blood NE, Cor and IMA in elderly patients with NSCLC
- Author(s):
- LUO Yechun
- Department of Cardiothoracic Surgery, Yulin Red Cross Hospital, Yulin 537000, China
- Keywords:
- Keywords: thoracoscope single port non-small cell lung cancer elderly oxidative injury pain stress
- PACS:
- R655.3
- DOI:
- DOI:10.3969/j.issn.1005-202X.2023.09.016
- Abstract:
- Abstract: Objective To explore the effects of single-port thoracoscopic surgery on the oxidative injury and the norepinephrine (NE), cortisol (Cor) and ischaemic modified albumin (IMA) in peripheral blood of elderly patients with non-small cell lung cancer (NSCLC). Methods According to surgical procedures, 94 elderly patients with NSCLC were divided into single-port group (n=46, single-port thoracoscopic surgery) and three-port group (n=48, traditional three-port thoracoscopic surgery). The surgical and laboratory data in both two groups were collected. The surgery-related indexes, changes in levels of serum pain mediators (NE, Cor) and IMA, oxidative stress indexes ［superoxide dismutase (SOD), malondialdehyde (MDA)］ and inflammatory factors ［interleukin-6 (IL-6), IL-8, C-reactive protein (CRP), tumor necrosis factor α (TNF-α)］ before and after surgery, and incidence of complications were compared between two groups. Results There was no significant difference in intraoperative blood loss or number of lymph nodes dissection between two groups (P>0.05). The patients in single-port group had longer operative duration but short hospital stay than those in three-port group (P<0.05). After surgery, the levels of NE, Cor, IMA, MDA, IL-6, IL-8, CRP and TNF-α in single-port group were lower than those in three-port group, while the level of SOD was higher than that in three-port group (P<0.05). The total incidence of postoperative complications in single-port group was 4.55%, lower than 19.75% in three-port group (P<0.05). Conclusion Single-port thoracoscopic surgery is less traumatic in NSCLC patients, and it can effectively relieve pain stress and oxidative injury, reduce risks of inflammatory response and complications, and is more conducive to postoperative recovery, with the same surgical efficacy as compared with three-port thoracoscopic surgery.
Last Update: 2023-09-26