Abstract

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Title:: Preliminary application of SuperMC in dose calculation for boron neutron capture therapy

Author(s):: ZHU Pu1; 2; WU Bin3; HE Peng3; 1. Science Island Branch, Graduate School of University of Science and Technology of China, Hefei 230026, China 2. Institute of Nuclear Energy Safety Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China 3. SuperSafety Science & Technology Co., Ltd, Hefei 230038, China

Keywords:: Keywords: boron neutron capture therapy dose calculation SuperMC Synder model

Abstract:: Abstract: Objective To develop a boron neutron capture therapy (BNCT) dose calculation framework with the automatic conversion of CT and MRI images to SuperMC inputs for further expanding SuperMC application as a dose calculation module in tumor radiotherapy. Methods The CT and MRI files were fused and the tumor area was delineated for high-precision Monte Carlo particle transport code programming. After setting the concentration of boron in the blood and irradiation source term, the particle transport based Monte Carlo calculation was carried out to obtain the spatial distributions of 4 kinds of biological doses. The correctness of dose results calculated using SuperMC was validated with BNCT benchmark (Synder model), and a clinical case of glioma was taken as a typical application. Results For Synder model, SuperMC results showed a good agreement with MCNP results according to "three sigma" rules. For the glioma case, a head model with a spatial resolution of 0.06 cm×0.06 cm×0.30 cm was successfully established, and the calculation results demonstrated that the contribution of boron biological dose was significantly higher than those of the other doses in the tumor area. Conclusion SuperMC is applicable to BNCT dose calculation, especially dose calculation based on high-resolution CT model.