Abstract

Info

Title:: HIFU passive cavitation imaging based on robust minimum variance and its advantages in damage monitoring

Author(s):: ZHOU Fang1; WANG Yongling2; FENG Lian1; CHEN Yanhua1; ZHOU Xiaowei1; 1. State Key Laboratory of Ultrasound in Medicine and Engineering/School of Biomedical Engineering, Chongqing Medical University, Chongqing 400016, China 2. National Engineering Research Center for Ultrasonic Medicine, Chongqing 401121, China

Keywords:: Keywords: high intensity focused ultrasound passive cavitation imaging cavitation detection inertial cavitation

Abstract:: Abstract: Based on the existing high intensity focused ultrasound (HIFU) clinical treatment system, passive cavitation detection and passive cavitation imaging technology are combined for the intraoperative monitoring of HIFU therapy, aiming to explore a damage monitoring strategy based on acoustic cavitation. The monitoring method adopts cavitation detection means to determine the cavitation threshold through the monitoring of the root mean square of cavitation signal and inertial cavitation dose, and uses robust minimum variance method to locate and image the location and intensity of cavitation. The experimental results show that under the conditions of in vitro and ex vivo, the treatment response in the target area can be well understood according to the cavitation activity map. In addition, the study focuses on verifying that the passive monitoring method based on cavitation phenomenon can eliminate the monitoring failures caused by the target deviating from the ultrasonic imaging plane to a certain extent, and proving that the proposed method is essentially superior to the active monitoring method based on ultrasonic images. The focused ultrasound monitoring technology based on cavitation phenomenon can improve the monitoring sensitivity and reliability, and it is expected to improve the safety and efficiency of clinical treatment.