Abstract

Info

Title:: Total-body CT simulation and image reconstruction method for total-body irradiation

Author(s):: GAO Zhengxin1; 2; XU Qiuyi1; 2; GONG Fei3; TAN Suhua1; 2; HONG Yaling1; 2; GONG Qing1; 2; SHI Fei1; 2; HU Qiaoying1; 2; YU Qi1; 2; FU Shen1; 2; 1. Shanghai Concord Cancer Center/Shanghai Concord Medical Outpatient Department, Shanghai 200020, China 2. State Key Laboratory of Radiation Medicine and Protection/Proton & Heavy Ion Medical Research Center, Soochow University, Suzhou 215213, China 3. Shanghai United Imaging Healthcare Co., Ltd., Shanghai 201807, China

Keywords:: Keywords: total-body CT scanning total-body irradiation technique image reconstruction

Abstract:: Abstract: Objective To explore a CT reconstruction method suitable for total-body irradiation (TBI), which can obtain a complete set of total-body CT images after continuous scanning at the same posture. Methods After CT simulation positioning using the TBI CT reconstruction method, a set of total-body CT images was generated in Eclipse v15.5 system, and it was applied to TBI planning and plan evaluation. Meanwhile, the corresponding image reconstruction software was developed based on Python system, and the reconstruction results were compared with manual image reconstruction results. Results The scanning protocol for the total-body simulation and positioning completed the reconstruction of two sets of CT images in Eclipse v15.5. The manual reconstruction method took 10 min on average to generate each set of total-body CT images, while the software only took 5 s. The image quality between the two CT image reconstruction methods did not differ significantly, and the error between the reconstructed CT and the real value was less than 1 mm. The TBI plan was formulated based on the reconstructed whole-body CT, and the plan evaluation showed that the conformity index and homogeneity index of target area were 0.854 and 0.199, respectively. Conclusion The total-body CT simulation and image reconstruction method for TBI can obtain a complete set of total-body CT images simply and quickly, which is suitable for the later TBI planning, optimization and evaluation.