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Title:: Advances in in vivo application of lead sulfide quantum dots assisted NIR-II fluorescence imaging technology

Author(s):: LI Hui1; ZHU Lijun1; ALIMU Gulinigaer1; YAN Ting1; ZHANG Xueliang2; ALIFU Nuernisha2; 1. School of Public Health, Xinjiang Medical University, Urumqi 830011, China 2. School of Medical Engineering and Technology, Xinjiang Medical University, Urumqi 830011, China

Keywords:: Keywords: lead sulfide quantum dot near-infrared spectral region Ⅱ fluorescence nanoprobe bio-medical application review

Abstract:: Abstract: Compared with the light in the traditional visible region (400-700 nm) and in the near-infrared spectral region Ⅰ (NIR-Ⅰ, 700-900 nm), the light in the near-infrared spectral region Ⅱ (NIR-Ⅱ, 900-1 700 nm) has longer wavelength and smaller scattering during propagation within biological tissues. NIR-II fluorescence imaging technology shows the advantages of deep penetrating capability in in vivo biological tissues and high spatiotemporal resolution. With the development of nanotechnology, NIR-II fluorescence emissive nanoprobes are gradually developed. Lead sulfide (PbS) quantum dots have become the research hotspot because of their advantages of adjustable size, adjustable bands, easy to modify and extremely high quantum yield. In recent years, PbS nanoprobe assisted NIR-II fluorescence imaging technology exerted a huge impact on the biomedical field, especially the animal imaging experiments of cardio-cerebrovascular, tumors and other many diseases. Herein the fluorescence properties and synthesis methods of PbS quantum dots are introduced, and the in vivo applications of PbS quantum dots under the modifications of a variety of substances are summarized, and an overview of PbS quantum dots assisted NIR-II fluorescence imaging in in vivo biological tissues such as the gastrointestinal tract, blood vessels, tumors, lymph nodes is gave, which paves the way for exploring the future potential of this imaging model.