Therapeutic effect of tomotherapy on lower thoracic esophageal cancer and its influences on cardiopulmonary function(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2023年第3期
- Page:
- 297-302
- Research Field:
- 医学放射物理
- Publishing date:
Info
- Title:
- Therapeutic effect of tomotherapy on lower thoracic esophageal cancer and its influences on cardiopulmonary function
- Author(s):
- JIANG Cong; LIANG Li; GAO Xufeng; HE Youan; LIU Qinsong; WANG Xianliang
- Radiotherapy Center, Sichuan Cancer Hospital, Chengdu 610042, China
- Keywords:
- Keywords: tomotherapy lower thoracic esophageal cancer cardiac function pulmonary function therapeutic effect
- PACS:
- R815
- DOI:
- DOI:10.3969/j.issn.1005-202X.2023.03.007
- Abstract:
- Abstract: Objective To analyze the curative effect of tomotherapy (TOMO) on lower thoracic esophageal cancer (EC) and to explore its affects on cardiopulmonary function. Methods A total of 105 patients with lower thoracic EC confirmed in Sichuan Cancer Hospital from June 2016 to June 2020 were prospectively enrolled. According to simple random number table method, they were divided into observation group (n=53) and control group (n=52). The patients in control group were treated with volumetric modulated arc therapy (VMAT), while those in observation group received TOMO. The clinical curative effect, target dosimetry parameters, cardiac function parameters and pulmonary function indexes were compared between two groups. At 1 year after radiotherapy, all were followed-up to record survival rates and tumor recurrence rates in both groups. Results The total clinical response rate in observation group was significantly higher than that in control group (62.26% vs 40.38%, P<0.05). The D2, D50 and HI of GTV and PTV in observation group were lower than those in control group (P<0.05), but CI was higher than control group (P<0.05). For the left lung, right lung and both lungs, compared with control group, observation group had higher V5 and Dmean (P<0.05), but lower V30 (P<0.05), and the differences in V20 were trivial (P>0.05). After radiotherapy, the levels of serum troponin and brain natriuretic peptide in both groups were increased, which were lower in observation group than in control group (P<0.05). There was no significant difference between observation group and control group in 1-year survival rate (86.79% vs 82.69%, P>0.05) and recurrence rate (P>0.05). Conclusion The treatment of lower thoracic EC with TOMO is efficient. TOMO can reduce cardiac damages and improve survival rate. However, there is no obvious advantage in pulmonary protection.
Last Update: 2023-03-30