Abstract

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Title:: Therapeutic efficacy of intense pulsed light combined with Nd:YAG laser for treatment of chloasma

Author(s):: SONG Ting; ZHANG Xiao; GAO Ni; SONG Pu; Department of Dermatology, the Fourth Military Medical University, Xian 710032, China

Keywords:: Keywords: melasma intense pulsed light Nd:YAG laser combined treatment

Abstract:: Abstract: Objective To investigate the clinical efficacy of intense pulsed light combined with Nd:YAG laser in the treatment of melasma. Methods According to different treatment methods, 60 patients were divided into 3 groups, namely intense pulsed light group, Nd:YAG laser group and combined treatment group (intense pulsed light combined with Nd:YAG laser group), with 20 patients in each group. The therapeutic efficacies and side effects of 3 groups were observed. Results The results of Mann-Whitney rank sum test for pairwise comparison on therapeutic efficacy showed that there was no significant difference between intense pulsed light group and laser group, and that the therapeutic efficacy of combined treatment group was significantly higher than that of intense pulsed light group (Z=7.123, P=0.024) and laser group (Z=6.024, P=0.030). All 60 patients had no adverse reactions such as aggravation of pigmentation and depigmentation disease. No significant difference was found in the degree of satisfaction between intense pulsed light group and laser group, but the degree of satisfaction of combined treatment group was significantly higher than that of the intense pulsed light group (Z=7.361, P=0.029) and laser group (Z=6.831, P=0.027). Conclusion Intense pulse light combined with Nd:YAG laser which is a safe and effective treatment method for melasma is worthy of clinical promotion.