Abstract

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Title:: Establishment and analysis of neuromodulation model based on multiple-electrode electrical stimulation

Author(s):: ZHANG Shuang1; 2; 3; YU Yuanyu1; WANG Jiujiang1; XU Jing1; KUANG Jiangming1; YANG Jining1; ZHANG Tao2; 3; 1.School of Artificial Intelligence, Neijiang Normal University, Neijiang 641112, China 2. School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, China 3. Sichuan Key Laboratory of High-Field Magnetic Resonance Brain Imaging, University of Electronic Science and Technology of China, Chengdu 611731, China

Keywords:: Keywords: transcranial electrical stimulation multiple-electrode electrical stimulation single-layer human head model neuromodulation finite element model

Abstract:: Abstract: Objective To analyze the diffusion of electrical stimulation signal in human tissues, thereby providing theoretical basis for multiple-electrode electrical stimulation. Methods A geometric structure model with the standard single-layer human head model in the electromagnetic simulation as the research object was adopted in the study. Assuming that the filler in the model was muscle tissues, a finite element model with muscle characteristics was established. Then, DC electrical signal of 20 mA was input to the model, and the signal transmission mechanism in the simplified head model was computed and analyzed by the multi-physics field simulation software COMSOL Multiphysics 5.5. Results The signal was mainly concentrated around the electrode. When using multi-electrode electrical stimulation, there was signal superposition at the geometric center of the model, and the signal at here had a trend of enhancement. Meanwhile, it was found through analysis on xy cross-section that in a homogeneous muscle tissue, the signal attenuation intensity was about 8 dB/cm. Conclusion In the simplified head model, multi-electrode electrical stimulation can form a signal enhancement trend at the geometric center of the cross-section of the head.