Effects of long-term mild hypothermia on brain injury markers and oxidative stress indexes in patients with severe traumatic brain injury(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2021年第12期
- Page:
- 1544-1548
- Research Field:
- 医学生物物理
- Publishing date:
Info
- Title:
- Effects of long-term mild hypothermia on brain injury markers and oxidative stress indexes in patients with severe traumatic brain injury
- Author(s):
- DU Yanping1; LIANG Jianguang1; WANG Yuhai2; JIN Dong1; HE Xinjun1; WU Chunfu1
- 1. Department of Neurosurgery, Wuxi Hospital of Traditional Chinese Medicine, Wuxi 214001, China 2. Department of Neurosurgery, Chinese PLA 904 Hospital，Wuxi 214044, China
- Keywords:
- Keywords: long-term mild hypothermia severe traumatic brain injury brain injury marker oxidative stress
- PACS:
- R318.52；R651.1
- DOI:
- DOI:10.3969/j.issn.1005-202X.2021.12.016
- Abstract:
- Abstract: Objective To investigate the effects of long-term mild hypothermia therapy for severe traumatic brain injury on brain injury markers and oxidative stress indexes. Methods Sixty-two patients with severe traumatic brain injury were divided into short-term (2 d) mild hypothermia group (control group, n=30) and long-term (5 d) mild hypothermia group (observation group, n=32) according to their therapy methods. After 6 days of treatment, coagulation function indexes, brain injury markers, oxidative stress indexes and occurrence of complications were compared between two groups. Moreover, coma duration, 30-day disability rate and 30-day mortality rate were observed during follow-up. Results After 6 days of treatment, compared with those in control group, the levels of serum prothrombin time, thrombin time, activated partial prothrombin time in observation group were higher (P<0.05), but the serum D-dimer level was lower (P<0.05). In addition, the levels of serum myelin basic protein, neuron specific enolase, S100 protein, malondialdehyde and superoxide dismutase in observation group were lower than those in control group (P<0.05). No significant difference was found in the incidences of intracranial hematoma, reduced gastrointestinal motility, urinary tract infection, pulmonary infection and stress ulcer between two groups (P>0.05). The coma duration of observation group was shorter than that of control group (P<0.05) and the 30-day disability rate and 30-day mortality rate of observation group were lower than those of control group, but there was no significant difference between two groups (P>0.05). Conclusion Long-term mild hypothermia can improve the coagulation function of patients with severe traumatic brain injury, reduce brain injury marker levels and oxidative stress injury, and shorten coma duration, without increasing the risk of complications.
Last Update: 2021-12-24