Dielectric properties of human glioma tissue at Larmor frequencies in MRI(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2021年第12期
- Page:
- 1538-1543
- Research Field:
- 医学生物物理
- Publishing date:
Info
- Title:
- Dielectric properties of human glioma tissue at Larmor frequencies in MRI
- Author(s):
- HUANG Wei1; XU Zhongbiao1; DENG Guanhua2; L?Fengquan1; LI Hainan3; CAI Linbo2; LIANG Yu1
- 1. Department of Radiation Oncology, Guangdong Provincial Peoples Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China 2. Department of Oncology, Guangdong Sanjiu Brain Hospital, Guangzhou 510510, China 3. Department of Pathology, Guangdong Sanjiu Brain Hospital, Guangzhou 510510, China
- Keywords:
- Keywords: glioma tissue open-ended coaxial line Larmor frequency electrical property
- PACS:
- R318.4
- DOI:
- DOI:10.3969/j.issn.1005-202X.2021.12.015
- Abstract:
- Abstract: Objective To investigate the dielectric properties of human glioma tissue at Larmor frequencies in MRI (50-500 MHz) and to establish the dielectric parameter frequency spectrum of human glioma tissue, thereby providing theoretical basis and reference data for magnetic resonance electrical property tomography (MREPT). Methods The glioma tissue which was removed from the brain during neurosurgery was taken as specimen. In a thermostatic water container with the temperature controlled at 37 °C, open-ended coaxial line method was used to measure the dielectric properties of human glioma tissue specimen via AV 3656A network analyzer at the frequencies between 50 MHz and 500 MHz. The dielectric characteristic parameters of human glioma tissue were obtained by the least square curve fitting method based on fourth-order Cole-Cole model. Finally, the dielectric properties of glioma tissue which were measured in the experiment were compared with those of normal brain tissue in a healthy human tissue dielectric property database. Results The measured data were fit closely with Cole-Cole model at the frequencies. The relative dielectric constant of human glioma tissue was 29.5%-36.6% high than that of the normal tissue and the conductivity was 56.1%-64.8% higher than that of normal tissue. Conclusion The dielectric properties of human glioma tissue are measured at Larmor frequencies in MRI (50-500 MHz) at 37 °C, and the dielectric characteristic parameters of the corresponding Cole-Cole model are also obtained in the study, which provide basic data for the research on the dielectric properties of human glioma tissue and MREPT.
Last Update: 2021-12-24