Abstract

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Title:: Effect of different radiotherapy techniques on hematological toxicity of craniospinal irradiation

Author(s):: ZHANG Yangqiong; YANG Huajun; LUO Rishun; DENG Guanhua; ZHANG Ping; CAI Linbo; Department of Oncology, Guangdong Sanjiu Brain Hospital, Guangzhou 510510, China

Keywords:: Keywords: craniospinal irradiation three-dimensional conformal radiotherapy intensity-modulated radiotherapy hematological toxicity bone marrow suppression

Abstract:: Abstract: Objective To investigate the effect of different radiotherapy techniques on hematological toxicity of craniospinal irradiation. Methods A retrospective study involving changes in hematology during craniospinal irradiation was conducted on 79 patients who were treated by craniospinal irradiation. The 36 patients in observation group received intensity-modulated radiotherapy, and 43 patients in control group underwent three-dimensional conformal radiotherapy.The prescribed dose of PTV in the two groups was 28.8-36.0 Gy, with 1.6-2.0 Gy each fraction. The hematological toxicity changes and bone marrow suppression stage of the two groups of patients before, during and after radiotherapy were recorded and analyzed. Results 90% of patients had different bone marrow suppression stages during and after radiotherapy. During radiotherapy, the toxicity of hemoglobin in observation group was more serious than that in the control group (z=-2.272, P=0.023).After radiotherapy, the toxicity of hemoglobin and white blood cells in observation group was more serious than those in control group (z=-3.053, P=0.002 z=-3.163, P=0.002). Conclusion The changes of hematological toxicity for craniospinal irradiation patient treated with IMRT should be closely observed compared with 3DCRT, and the corresponding preventive measures should be taken to avoid serious bone marrow suppression.