Abstract

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Title:: Application of quantum dot probes assisted near-infrared fluorescence imaging technology in tumor imaging

Author(s):: FAN Huimin; ZHU Lijun; MA Yan; ALIFU Nuernisha; State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia/School of Medical Engineering and Technology, Xinjiang Medical University, Urumqi 830011, China

Keywords:: Keywords: near-infrared quantum dot probe tumor imaging fluorescence imaging review

Abstract:: Abstract: Early tumor detection is a key factor for precise diagnosis and effective treatment of cancer. With the advantages of high sensitivity, excellent temporal and spatial resolutions, non-ionizing radiation, non-invasive and real-time imaging, fluorescence imaging technology has showed broad application prospects in biomedicine, especially in tumor detection. When near-infrared light penetrates biological tissues, there were less light absorption and scattering. Therefore, near-infrared light has high signal-to-noise ratio and deep tissue penetration in bioimaging. Among various fluorescent probes, near-infrared fluorescent quantum dot probes show outstanding properties in fluorescence imaging, such as high quantum yield, strong resistance to photobleaching, adjustable emission light and good stability. Herein the application of quantum dot probes assisted near-infrared fluorescence imaging technology in tumor imaging was reviewed and the excellent optical properties of quantum dots were introduced and the advances of research on lead sulfide (PbS) and silver sulfide (Ag2S) near-infrared fluorescence quantum dot probes in tumor imaging were mainly summarized and finally the application prospects of near-infrared fluorescent quantum dot probes is discussed.