Abstract

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Title:: Monte Carlo calculation of internal radiation absorbed dose of radiopharmaceutical 18F-AV45 in brain tissues based on PET-CT image

Author(s):: LI Yongzhe1; LU Yu1; PENG Zhao1; NI Ming2; XIE Qiang2; WANG Shicun2; PEI Xi1; XU Xie1; CHEN Zhi1; 1. School of Nuclear Science and Technology, University of Science and Technology of China, Hefei 230026, China 2. Department of Nuclear Medicine, the First Affiliated Hospital of University of Science and Technology of China, Hefei 230001, China

Keywords:: Keywords: positron emission tomography-computed tomography Monte Carlo internal radiation absorbed dose biokinetic model

Abstract:: Abstract: Objective To calculate the absorbed dose of radiopharmaceutical 18F-AV45 in the head and various organs and tissues of the head. Methods After collecting the PET-CT images of 5 patients, Monte Carlo software GATE was used to calculate the absorbed dose per unit decay number in the head, and a biokinetic model was utilized to calculate the cumulative decay number of the head, thereby obtaining the total absorbed dose in the head. Finally, various organs and tissues of the head were segmented in the CT images, and their absorbed doses were also calculated. Results The average absorbed dose per unit decay number in the heads of 5 patients was found to be 4.29×10-6, 4.48×10-6, 4.39×10-6, 4.49×10-6 and 4.29×10-6 mGy/(MBq·s), respectively, and the average statistical uncertainty of Monte Carlo simulation was 2.6%. The absorbed dose accumulated in the heads of 5 patients was 0.39, 0.59, 1.17, 1.01 and 0.71 mGy, respectively. The average absorbed doses in 12 organs and tissues of the head of patient 4 were calculated. Conclusion The calculation of the absorbed dose of radiopharmaceutical 18F-AV45 in the human head and various organs and tissues of the head is realized in the study.