|Table of Contents|

Dynamic functional connectivity of brain networks in patients with low back pain(PDF)

《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

Issue:
2021年第9期
Page:
1084-1089
Research Field:
医学影像物理
Publishing date:

Info

Title:
Dynamic functional connectivity of brain networks in patients with low back pain
Author(s):
JIA Runhui1;  WANG Xinzhu1;  CHEN Xiaofei1;  DONG Fuwen1;  ZHOU Sheng1;  YU Lianchun2;  CHEN Qiqing3
1. Department of Radiology, Gansu Provincial Hospital of TCM, Lanzhou 730050, China 2. School of Physical Science and Technology, Lanzhou University, Lanzhou 730000, China 3. Department of Orthopaedic Spine, Gansu Provincial Hospital of TCM, Lanzhou 730050, China
Keywords:
low back pain magnetic resonance imaging dynamic functional connectivity functional flexibility
PACS:
R445.2；R318
DOI:
10.3969/j.issn.1005-202X.2021.09.007
Abstract:
Objective To explore the dynamic functional connectivity of brain networks in low back pain (LBP) patients. Methods The resting-state functional magnetic resonance imaging was performed on 20 LBP patients and 20 normal controls. The dynamic functional connectivity between LBP patients and normal controls was compared using connectivity number entropy (CNE), and the correlations between functional flexibility of each independent brain region in LBP patients and age and JOA scale score were also analyzed. Results The CNE of LBP patients was lower than that of normal controls at the whole brain level (P<0.05), and the brain regions with significant changes were concentrated in frontal cortex, temporal cortex, subcortical nucleus mass and part of occipital cortex. Locally, some brain regions such asAAL15 (r=-0.525 5, P=0.020 8),AAL32 (r=-0.529 2, P=0.019 8),AAL41 (r=-0.546 9, P=0.015 4), AAL 62 (r=0.601 5, P=0.006 4), AAL 76 (r=-0.513 3, P=0.024 6), AAL 89 (r=0.461 9, P=0.046 5) and AAL90 (r=0.508 5, P=0.026 2) had clinical relevance to age, and others brain regions, includingAAL17 (r=-0.499 1, P=0.029 6), AAL 47 (r=0.481 4, P=0.036 9), AAL 82 (r=-0.554 8, P=0.013 7) and AAL 90 (r=-0.562 1, P=0.012 3), were correlated with JOA scale score. Conclusion The functional flexibility of brain networks in LBP patients is reduced at the whole brain level. The measurement of CNE for evaluating dynamic functional connectivity not only provides a new framework for quantifying spatial and temporal behaviors of brain activity, but also can be used to explore the mechanism of brain function changes in LBP patients.

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Last Update: 2021-09-27