Abstract

Info

Title:: Dose-guided adaptive prescribed dose optimization method in intensity-modulated radiotherapy

Author(s):: YIN Chuou; YANG Peng; ZHANG Shengyuan; CUI Fengjie; WANG Ningyu; GU Shaoxian; HU Jinyou; WU Zhangwen; GOU Chengjun; Key Laboratory for Radiation Physics and Technology of Ministry of Education/Institute of Nuclear Science and Technology, Sichuan University, Chengdu 610064, China

Keywords:: Keywords: intensity-modulated radiotherapy prescribed dose optimization treatment planning system

Abstract:: Abstract: Objective The prescribed dose of each voxel in objective function is automatically optimized according to the difference between prescribed dose and the actual dose, thereby realizing the optimization of treatment plan quality. Methods The proposed adaptive prescribed dose optimization algorithm and the conventional prescribed dose setting method were used for treatment planning and optimization. The dose-volume histogram and the related dosimetric parameters between 2 kinds of plans were compared. Results Compared with conventional plan, adaptive plan had a lower maximum dose to the target area, and less number of hot spots and a more uniform dose distribution. In addition, the dose to organs-at-risk was decreased in adaptive plan. After plan optimization, all dosimetric parameters meet the dose goals. Conclusion Adaptive prescribed dose optimization method is able to optimize the treatment plans, and it can be integrated into the treatment planning system used for clinic.