Therapeutic effects of intensity-modulated radiotherapy and conventional radiotherapy on breast cancer after modified radical mastectomy and their effects on the heart and lungs(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2021年第2期
- Page:
- 168-171
- Research Field:
- 医学放射物理
- Publishing date:
Info
- Title:
- Therapeutic effects of intensity-modulated radiotherapy and conventional radiotherapy on breast cancer after modified radical mastectomy and their effects on the heart and lungs
- Author(s):
- LI Kan; DU Qingan
- Department of General Surgery, Taikang Xianlin Drum Tower Hospital, Medical College of Nanjing University, Nanjing 210000, China
- Keywords:
- Keywords: breast cancer modified radical mastectomy intensity-modulated radiotherapy conventional radiotherapy heart lung
- PACS:
- R737.9；R815
- DOI:
- DOI:10.3969/j.issn.1005-202X.2021.02.008
- Abstract:
- Abstract: Objective To investigate the therapeutic effects of intensity-modulated radiotherapy (IMRT) and conventional radiotherapy (CRT) after modified radical mastectomy for breast cancer, and to study the effects of different radiotherapy modalities on the heart and lungs. Methods Sixty patients undergoing modified radical mastectomy for breast cancer were enrolled and divided into observation group (30 cases) and control group (30 cases) according to different radiotherapy modalities. The patients in observation group were treated with IMRT, while those in control group were treated with CRT. The short-term therapeutic effect, cardiac troponin and pulmonary function before and after radiotherapy, and the dosimetric indexes of the affected lung and the heart were compared between two groups. Results There was no significant difference in short-term therapeutic effect between two groups (P>0.05). The level of troponin in both two groups after radiotherapy was higher than that before radiotherapy (P<0.05), but the level of troponin in observation group after radiotherapy was lower than that in control group (P<0.05). After radiotherapy, the ejection fraction in both two groups was decreased, while LADs and LVDd were increased (P<0.05). Compared with those in control group, the ejection fraction in observation group after radiotherapy was higher, but LADs and LVDd were much lower (P<0.05). The difference between two groups in the V95 of the affected lung was insignificant (P>0.05), while the V105 and V110 of the affected lung in observation group were lower than those in control group (P<0.05). Moreover, the heart index V30, V40 and V50 in observation group were lower than those in control group (P<0.05). Conclusion The therapeutic effects of IMRT and CRT for breast cancer after modified radical mastectomy are similar, and moreover, IMRT has trivial effects on the heart and lungs, thereby reducing radiation-induced damages to the heart and lungs.
Last Update: 2021-02-02