Abnormal resting-state functional connectivity of the locus coeruleus in patients with chronic insomnia(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2021年第6期
- Page:
- 699-703
- Research Field:
- 医学影像物理
- Publishing date:
Info
- Title:
- Abnormal resting-state functional connectivity of the locus coeruleus in patients with chronic insomnia
- Author(s):
- LI Chunlong1; JIANG Guihua1; 2; MA Xiaofen2; LI Shumei2; LAN Zhihong2; HUANG Shumei1
- 1. the First Clinical Medical College, Guangdong Medical University, Zhanjiang 524023, China 2. Department of Imaging, Guangdong Second Provincial General Hospital, Guangzhou 510317, China
- Keywords:
- Keywords: chronic insomnia locus coeruleus default mode network resting-state functional connectivity
- PACS:
- R318；R445.2
- DOI:
- DOI:10.3969/j.issn.1005-202X.2021.06.008
- Abstract:
- Abstract: Objective To investigate the abnormal resting-state functional connectivity of the locus coeruleus in patients with chronic insomnia using functional connectivity analysis. Methods A total of 49 patients with chronic insomnia and 47 gender-, age- and education-matched healthy controls were examined with resting-state functional magnetic resonance imaging (fMRI) in the study. The locus coeruleus in fMRI image was selected as the region of interest, and then functional connectivity analysis was conducted on the locus coeruleus and other voxels in the brain for obtaining the brain regions with different functional connectivity between two groups. The correlation between the functional connectivity value of the brain region with abnormal functional connectivity and clinical scale score was also analyzed. Results Compared with that in control group, the functional connectivity between the locus coeruleus and multiple brain regions (including right precuneus, right posterior cingulate cortex, left middle temporal gyrus, left calcarine periphery cortex and right superior orbitofrontal cortex) was significantly enhanced (P<0.05, FDR correction), and the functional connectivity value between the locus coeruleus and left middle temporal gyrus was positively correlated with the score of self-rating depression scale (P=0.021). Conclusion The abnormal functional connectivity between the locus coeruleus and multiple brain regions (mainly default mode network) in patients with chronic insomnia may contribute to understanding the neurobiological mechanism of chronic insomnia, and may provide new imaging evidence for the high arousal hypothesis of insomnia.
Last Update: 2021-06-29