Value of DNA detection of Epstein Barr virus in the analysis of curative effect of intensity-modulated radiation therapy for nasopharyngeal carcinoma(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2020年第12期
- Page:
- 1502-1505
- Research Field:
- 医学放射物理
- Publishing date:
Info
- Title:
- Value of DNA detection of Epstein Barr virus in the analysis of curative effect of intensity-modulated radiation therapy for nasopharyngeal carcinoma
- Author(s):
- LI Geng; GAO Jianquan
- Radiotherapy Zone 3, Wuzhou Red Cross Hospital, Wuzhou 543000, China
- Keywords:
- Keywords: nasopharyngeal carcinoma EB virus DNA detection intensity-modulated radiation therapy
- PACS:
- R739.6；R816.96
- DOI:
- DOI:10.3969/j.issn.1005-202X.2020.12.006
- Abstract:
- Abstract: Objective To explore the value of DNA detection of Epstein Barr (EB) virus in the analysis of curative effect of intensity-modulated radiation therapy (IMRT) for nasopharyngeal carcinoma. Methods 50 nasopharyngeal carcinoma patients who were treated in the radiotherapy zone 3 of the oncology department of Wuzhou Red Cross Hospital were selected as the research objects and were treated with IMRT radiotherapy. Their peripheral blood samples were tested before, during, and immediately after the radiotherapy and were retested in six, nine, twelve, and eighteen months after the radiotherapy. Based on the DNA detection of EB virus by fluorescence quantitative PCR, the relationship between EB virus DNA concentration and short-term efficacy of nasopharyngeal carcinoma, overall survival (OS), progression-free survival (PFS), disease-free survival (DFS), recurrence-free survival (RFS) was analyzed. Results From the patients receiving radiotherapy to the end of follow-up, the positive rate of DNA decreased from 63.2% (before the radiotherapy), 30.1% (during radiotherapy) and 10.6% (immediately after radiotherapy) to 5.35% in the reexamination when 18 months after radiotherapy, showing a downward trend over time. This result was consistent with OS, PFS, DF and RFS in recent efficacy evaluation and survival analysis. Conclusion The efficacy of liberation therapy and prognosis can be determined and evaluated by detecting the DNA of EB virus in patients with nasopharyngeal carcinoma.
Last Update: 2020-12-30