Study on primary insomnia based on multimodal functional MRI(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2020年第12期
- Page:
- 1534-1539
- Research Field:
- 医学影像物理
- Publishing date:
Info
- Title:
- Study on primary insomnia based on multimodal functional MRI
- Author(s):
- CHEN Guanfeng1; LI Xiumei2; SUN Bingqing1; HUANG Risheng1
- 1. Department of Imaging, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou 362000, China 2. Department of Imaging, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China
- Keywords:
- Keywords: primary insomnia multimodal functional MRI neural network PSQI HAMD HAMA
- PACS:
- R318；R816.1
- DOI:
- DOI:10.3969/j.issn.1005-202X.2020.12.012
- Abstract:
- Abstract: Objective To study primary insomnia based on multimodal functional magnetic resonance imaging (MFMRI). Methods 50 primary insomnia patients admitted to our hospital from December 2018 to December 2019 were selected as the research group, and 50 healthy people with matching gender and age were selected as the control group. All the subjects were evaluated by clinical PSQI, HAMD and HAMA, and PCC was chosen as seed point to make the FC analysis on resting fMRI data to obtain the brain functional connection parameters of the subjects. The differences between the study group and the control group were compared and analyzed finally. Results There was no statistical difference in gender and age between the control group and the study group, but PSQI, HAMD and HAMA scores in the research group were higher than those in the control group (P<0.05). There was no difference in DTI between the control group and the study group. Compared with the control group, the FA values of the left hippocampus and the right superior frontal occipital tract in the research group were significantly decreased, while the MD values of the bilateral cingulate gyrus, the left inferior longitudinal tract, the right superior frontal occipital tract, the left hippocampus and the bilateral uncinate tract were significantly increased (P<0.05). The functional connectivity of PCC to the subjects brain area in the control group such as temporal pole L/temporal superior gyrus/frontal superior gyrus/insular, temporal pole R/insular, suboccipital gyrus R/fusiform gyrus, frontalis inferior R/frontalis pars orbitalis, etc. was done with the threshold P=0.000 and clusters≥1 355 mm3. The functional connectivity of PCC to the subjects’ brain area such as frontalis inferior pars orbitalis L/temporal superior gyrus/frontal middle gyrus, precuneus L, R/posterior cingulate/intermediate cingulate gyrus, etc. was done with the threshold P=0.000, and clusters ≥ 1 355 mm3. Conclusion The combination of fMRI and DW-RMI can reveal the pathophysiological mechanism of primary insomnia as a multimodal way.
Last Update: 2020-12-30