Timing of intervention and therapeutic efficacy of adjuvant hyperbaric oxygen therapy against
COVID-19(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2020年第5期
- Page:
- 641-643
- Research Field:
- 医学影像物理
- Publishing date:
Info
- Title:
- Timing of intervention and therapeutic efficacy of adjuvant hyperbaric oxygen therapy against
COVID-19
- Author(s):
- YANG Yong1; WU Muyu1; MIAO Lixia2; HE Cong3
- 1. Department of Geriatric Medicine, Affiliated Dongfeng Hospital, Hubei University of Medicine, Shiyan 442008, China 2. Department
of Critical Care Medicine, Affiliated Dongfeng Hospital, Hubei University of Medicine, Shiyan 442008, China 3. Department of Hyperbaric
Oxygen, Affiliated Dongfeng Hospital, Hubei University of Medicine, Shiyan 442008, China
- Keywords:
- COVID-19 adjuvant hyperbaric oxygen timing of intervention hospital stay
- PACS:
- R459.6；R563.1
- DOI:
- 10.3969/j.issn.1005-202X.2020.05.021
- Abstract:
- Objective To investigate the therapeutic efficacy of adjuvant hyperbaric oxygen therapy (HBO) against COVID-19 and
the effects of timing of intervention on the efficacy. Methods The clinical information of 88 patients whomet the criteria for COVID-
19 protocol (the fifth trial edition) and were treated inAffiliated Dongfeng Hospital, Hubei University of Medicine from January
to March in 2020 were studied retrospectively. A according to treatment methods, the patients were divided into conventional
treatment group (n=50) and adjuvant HBO group (n=38). The differences in the indexes including the time of negative
transformation of nucleic acid, the time of CT improvement, the time of lymphocyte normalization and hospital stay between two
groups were compared. Meanwhile, 33 patients with ordinary type of COVID-19 in adjuvant HBO group were further divided
into early phase group (1-10 days after admission to hospital, n=15) and late phase group (>10 days after admission to hospital,
n=18 patients) to compare the differences in hospital stays. Results Compared with those in conventional treatment group, the
patients in adjuvant HBO group achieved the negative transformation of nucleic acid, CT improvement and lymphocyte
normalization earlier, and had a shorter hospital stay in adjuvant HBO group was shorter than that in conventional treatment group.
Moreover, the hospital stay in early phase group was shorter than that in late phase group, with statistical differences (P<0.05).
Conclusion Adjuvant HBO plus conventional treatment can accelerate the time of negative transformation of nucleic acid, CT
improvement, lymphocyte normalization, and shorten hospital stays, and the earlier HBO is adopted, the shorter the hospital stay
is.
Last Update: 2020-06-03