Diagnostic value of technetium-99m methoxy-isobutyl-isonitrile for thyroid nodules(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2020年第8期
- Page:
- 1030-1034
- Research Field:
- 医学影像物理
- Publishing date:
Info
- Title:
- Diagnostic value of technetium-99m methoxy-isobutyl-isonitrile for thyroid nodules
- Author(s):
- WEI Li1; HU Yulin2; XIAO Han3; FAN Yixiang2
- 1. Department of Oncology,No.971 Hospital of PLA Navy, Qingdao 266071, China 2. Department of Nuclear Medicine, the Fifth Affiliated Hospital of Southern Medical University, Guangzhou 510900, China 3. Department of Nuclear Medicine, Guangdong Second Provincial General Hospital, Guangzhou 510317, China
- Keywords:
- Keywords: thyroid nodule radionuclide imaging tomography emission computed tomography single photon technetium-99m methoxy-isobutyl-isonitrile
- PACS:
- R817.9
- DOI:
- DOI:10.3969/j.issn.1005-202X.2020.08.017
- Abstract:
- Abstract: Objective To evaluate the value of radionuclide imaging with technetium-99m methoxy-isobutyl-isonitrile (99Tcm-MIBI) for the differential diagnosis of benign and malignant thyroid nodules. Methods A total of 165 patients with thyroid nodules confirmed by ultrasound and pathological diagnosis postoperatively were included in the study. All patients received 99TcmO4- thyroid imaging and the "cold or cool nodules" were judged based on the image. 99Tcm-MIBI thyroid imaging, including early imaging and delayed imaging, was performed the next day. Early imaging or/and delayed imaging showed abnormal uptake of 99Tcm-MIBI on the original "cold /cool nodules", which was assessed to be positive. The uptake T/N ratio of 99Tcm-MIBI at the nodules was determined by region-of-interest technique. Thyroid cancer nodules were grouped according to their lengths and diameters, and the positive detection rate of each group was calculated. On the basis of pathological results, the sensitivity,specificity, positive predictive value, negative predictive value and accuracy of 99Tcm-MIBI thyroid imaging were calculated. The T/N ratio of nodules between early imaging and delayed imaging in thyroid cancer group, and the T/N ratio of nodules in early imaging and delayed imaging between thyroid cancer and benign thyroid nodules were compared by t-test. The positive detection rates of different nodule size groups were compared by Chi-Square test. Results Among the 165 patients, 97 were diagnosed with thyroid cancer and 68 were diagnosed with benign thyroid nodules by postoperative pathology. The diagnostic sensitivity, specificity, positive predictive value, negative predictive value and accuracy of 99Tcm-MIBI imaging for thyroid nodules was 84.5%(82/97), 76.4% (52/68), 83.6%(82/98), 77.6%(52/67) and 81.2%(134/165), respectively. The T/N ratios in the early imagingand delayed imaging of thyroid cancer were significantly higher than those of benign thyroid nodules (t=2.706 6, P<0.005 t=2.398 1, P<0.01). For the thyroid cancer nodule grouped according to their lengths (≤10 mm, 10-19 mm, 20-29 mm and ≥30 mm groups), the positive detection rate of thyroid cancer nodules was 74.1% in 20-29 mm group and 91.6% in ≥30 mm group.There was no statistical differences in positive detection rate between 20-29 mm group and ≥30 mm group ([χ2]=3.575 9, P>0.05), but the positive detection rate of 20-29 mm group was significantly higher than that of 10-19 mm group ([χ2]=3.857 1, P<0.05) and that of <10 mm group ([χ2]=8.851 7, P<0.01). Conclusion 99Tcm-MIBI thyroid imaging has a good diagnostic value for thyroid nodules. Compared with benign thyroid lesions, thyroid cancer has a higher uptake of 99Tcm-MIBI. When the length of thyroid cancer nodules are greater than 20 mm, a high positive rate of diagnosis can be obtained, and the size of nodules is an important factor affecting the diagnostic sensitivity of thyroid cancer.
Last Update: 2020-08-27