Abstract

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Title:: Development of a device for photodynamic therapy combining pure oxygen with LED array

Author(s):: HUANG Renxiang1; WANG Xiaohui2; GUO Nanping1; LIN Shanli2; BIAN Yanxiang1; WANG Yan2; ZHOU Yuhui2; 1. Guangzhou Race Medical & Beauty Equipment Co., Ltd., Guangzhou 510555, China 2. Guangzhou Biotechnology Center, Guangzhou 510630, China

Keywords:: Keywords: photodynamic therapy complex treatment singlet oxygen lens array hypoxia light sorting

Abstract:: Abstract: A novel treatment device for photodynamic therapy combining with pure oxygen and LED array is developed. The device can produce pure oxygen based on the principle of pressure swing adsorption, and there is a photodynamic therapy irradiator established by micro-lens array multi-wavelength LED and secondary lens array. The concentration of pure oxygen output by irradiator is higher than 90%. The light sources include 625 nm red light, 465 nm blue light and 520 nm green light. The pure oxygen combined with multi-spectral photodynamic therapy is realized by light sorting irradiation technology. The problem that the therapeutic effect of photodynamic therapy is affected by the lack of oxygen is solved by a variety of exogenous oxygen such as the synchronous output of pure oxygen and light by the irradiator to maintain the photodynamic therapy area in oxygen-enriched environment. Moreover, the optical system of the irradiator takes LED array arrangement instead of laser as the light source of photodynamic therapy, thereby overcoming the defects of low utilization of light energy, uneven distribution of optical power density and large difference in the optical power density distribution surface of lights of different wavelengths on the target surface.