Correlation between T-SPOT.TB assay and pulmonary CT findings in pulmonary tuberculosis(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2020年第9期
- Page:
- 1155-1159
- Research Field:
- 医学人工智能
- Publishing date:
Info
- Title:
- Correlation between T-SPOT.TB assay and pulmonary CT findings in pulmonary tuberculosis
- Author(s):
- YANG Chaosheng1; CHEN Hui1; SUN Xuejiao1; ZHANG Dongwei1; LIU Qiongxia1; WANG Feng1; LIU Zisheng2
- 1. Department of Respiratory and Critical Care Medicine, Liuzhou Peoples Hospital, Liuzhou 545000, China 2. Department of Digestion,
Chenzhou No.1 Peoples Hospital, Chenzhou 423000, China
- Keywords:
- pulmonary tuberculosis T-SPOT.TB assay high-resolutiion CT
- PACS:
- R521；R814.42
- DOI:
- 10.3969/j.issn.1005-202X.2020.09.014
- Abstract:
- Objective To investigate the relationship between the results of T-SPOT.TB assay and high-resolution CT (HRCT) sign
scores of patients with active pulmonary tuberculosis (PTB). Methods The clinical information of 52 patients with PTB was
retrospectively analyzed in the study. Peripheral blood samples were collected for detecting the T lymphocytes by T-SPOT.TB
assay, and meanwhile the pulmonary CT findings were scored according to the 7 typical patterns, distributions and profusions of
pulmonary abnormalities on HRCT images. Finally, scattered spots were drawn and the correlations between the results of T-SPOT.
TB assay and HRCT sign scores were investigated by statistical software. Results The HRCT sign scores in 52 patients ranged
from 2 to 52. The score of micronodules was the highest, with a total score of 254 and an average score of 4.88, while the score
of the cavity was the lowest, with a total score of 10 and an average score of 0.19. Generally, the HRCT sign scores were normally
distributed. The results of T-SOPT.TB assay showed that T-SPOT.TB antigen A were negative (the measured values were 0-5) in
17 cases and positive (the measured values were larger than 5) in the other samples, and that there were 14 T-SPOT.TB antigen
B negative (the measured values were 0-5) cases and 38 positive (the measured values were larger than 5) cases. There was no
statistical difference in the average HRCT sign score between T-SPOT.TB negative cases and T-SPOT.TB positive cases (whatever
T-SPOT.TB antigen A or B). According to the drawn scatter plots, T-SPOT.TB antigens A and B detected by T-SPOT.TB were
correlated with HRCT sign scores in a certain degree, and the corresponding correlation coefficients were 0.27 (P<0.05) and 0.17
(P<0.05), respectively, which suggested there was positive correlation between the results of T-SPOT.TB assay and HRCT sign
scores. Conclusion T-SOPT.TB has a correlation with the range and degree of PTB lesions on HRCT image.
Last Update: 2020-09-25