Application of beam angle optimization in intensity-modulated radiotherapy planning for esophageal cancer(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2020年第4期
- Page:
- 413-418
- Research Field:
- 医学放射物理
- Publishing date:
Info
- Title:
- Application of beam angle optimization in intensity-modulated radiotherapy planning for esophageal cancer
- Author(s):
- ZHANG Jun1; 2; PENG Yinglin2; ZHU Jinhan2; LIU Yimei2; CHEN Meining2; DENG Xiaowu2; ZHOU Linghong1
- 1. School of Biomedical Engineering, Southern Medical University, Guangzhou 510515, China; 2. Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China
- Keywords:
- Keywords: beam angle optimization; intensity-modulated radiotherapy; esophageal cancer; comprehensive scoring factor
- PACS:
- R815.2
- DOI:
- DOI:10.3969/j.issn.1005-202X.2020.04.004
- Abstract:
- Abstract: Objective To study the dosimetric differences among 5-field intensity-modulated radiotherapy (5f-IMRT) plans designed by beam angle optimization (BAO), uniform field distribution or artificial field distribution for providing clinical reference for the IMRT planning for esophageal cancer. Methods Fifteen patients with esophageal cancer treated with IMRT were selected, and 3 kinds of 5f-IMRT plans were designed for each patient, namely BAO group (group A), uniform field distribution group (group B) and artificial field distribution group (group C). The target coverage, conformity index, homogeneity index of target areas and the dosimetric parameters of organs-at-risk were used to compare the dosimetric differences among 3 groups. Paired-t test was used for statistical analysis. Results The target coverage of all 3 groups met the clinical requirements. The mean doses of the lung and the heart in group A were significantly lower than those in the other two groups, with statistical significance (P<0.05). Compared with those in group C, the lung V20 Gy and heart V30 Gy in group A and group B were significantly lower (P<0.05). The lung V20 Gy of A vs C and B vs C were ［(29.15±2.75)% vs (30.03±2.55)%, P=0.005］ and ［(29.08±2.40)% vs (30.03±2.55)%, P=0.005)］, respectively, and the heart V30 Gy were ［(45.37±4.59)% vs (48.24±6.45)%, P=0.010)］ and ［(45.79±4.60)% vs (48.24±6.45)%, P=0.040)］, respectively. Finally, the dosimetric parameters of 3 groups were evaluated to obtain comprehensive scoring factor-based scores (CSF). The CSFPTVx, CSFOAR and CSFTotal in group A were the highest, and CSFTotal reached 7; and group C had the worst CSFTotal which was -4. Conclusion BAO plan for esophageal cancer has obvious dosimetric advantages over the 5f-IMRT plans designed by uniform field distribution and artificial field distribution, which suggests that BAO plan should be popularized and applied in the treatment planning for esophageal cancer.
Last Update: 2020-04-29