Abstract

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Author(s):: GAO Feng1; CAO Lulu1; 4; YANG Yiwei2; DU Xiaobo1; DAI Tangzhi1; WU Dai3; 1. Mianyang Central Hospital, Mianyang 621000, China 2. Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, Mianyang 621900, China 3. Institute of Applied Electronics, China Academy of Engineering Physics, Mianyang 621900, China 4. North Sichuan Medical College, Nanchong 637000, China

Keywords:: Flash radiotherapy platform for advanced radiotherapy research radiotherapy dose Monte Carlo simulation

Abstract:: Flash radiotherapy (Flash-RT) which is an international cutting-edge technology and hotspot in the domain of tumor radiotherapy in recent years delivers all the treatment dose into the target area in an ultra-short time (about 1-50 ms) at ultra-high dose rate (usually >100 Gy/s). Various researches revealed that Flash-RT could significantly reduce the time of radiotherapy and bring less damage to normal tissues. The superconducting electron accelerator of the CTFEL facility in China Academy of Engineering Physics can produce 6-8 MeV electron beam up to 5 mA in average current, and the platform for advanced radiotherapy research (PARTER) based on the superconducting electron accelerator should be a suitable platform for Flash-RT research. Herein PARTER and the detailed design schemes of Flash-RT specific targets and collimators are firstly introduced. According to Monte Carlo simulation, the maximum dose rate for the biological samples on the platform was up to 2 000 Gy/s, and the exposure time was continuously adjustable from μs to 100 ms, and the coverage depth for dose rate larger than 100 Gy/s was more than 20 cm, which meet the requirements of Flash-RT research. The detailed calculation process and result analysis are described for providing some basic reference data for the following Flash-RT experiments which are carried out on PARTER.