Abstract

Info

Title:: Comparison of therapeutic effects of intensity-modulated radiotherapy with different dose schemes following breast-conserving surgery for early-stage breast cancer

Author(s):: CHEN Rixin1; LUO Zhanxiong1; QIN Jianing1; ZHU Zhou1; JIA Yanhua1; WANG Zhi2; 1. Department of Medical Oncology, Liuzhou Peoples Hospital, Liuzhou 545006, China 2. Department of General Practice, Affiliated Hospital of Xiangnan University, Chenzhou 423000, China

Keywords:: Keywords: breast cancer breast-conserving surgery intensity-modulated radiotherapy irradiation dose

Abstract:: Abstract: Objective To analyze the therapeutic effects of intensity-modulated radiotherapy with different dose schemes after breast-conserving therapy for early-stage breast cancer. Methods Fifty patients receiving surgery for breast cancer were divided into two groups according to the irradiation dose. The total radiotherapy dose was 50 Gy in group A and 60 Gy in group B. The intervention effect and safety of the two schemes were analyzed. Results There were significant differences between two groups in V99%, V109% and V115% (P<0.05), but not in V100% ［(55.13±6.28)% vs (54.26±6.01)%］. The 3-year?elapse rate in group A was 12%, higher than 4% in group B (P<0.05). Moreover, the incidence of radiodermatitis of grade Ⅰ and below in group A was obviously lower than that in group B (44.00% vs 72.00%, P<0.05), and no significant difference was found in the incidence of radiodermatitis of grade Ⅱ and grade III and above. Conclusion The main treatment scheme for patients with early-stage breast cancer is breast-conserving therapy, and the key auxiliary measure is radiotherapy in which different dose schemes can affect the therapeutic effect, and an appropriate high dose scheme can improve the overall therapeutic effect.