Different optimization methods in hypofractionated radiotherapy for breast cancer: a dosimetric study(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2020年第7期
- Page:
- 843-849
- Research Field:
- 医学放射物理
- Publishing date:
Info
- Title:
- Different optimization methods in hypofractionated radiotherapy for breast cancer: a dosimetric study
- Author(s):
- SHAO Ying1; 2; WANG Yadi1; WANG Shi3; ZHANG Fuli1
- 1. Department of Radiotherapy, the Seventh Medical Center, Chinese PLA General Hospital, Beijing 100700, China 2. Department of Radiotherapy, Beijing Tsinghua Changgung Hospital Affiliated to Tsinghua University, Beijing 102218, China 3. Department of Engineering Physics, Tsinghua University, Beijing 100084, China
- Keywords:
- Keywords: breast cancer equivalent uniform dose hypofractionated radiotherapy dosimetry
- PACS:
- R737.9；R815
- DOI:
- DOI:10.3969/j.issn.1005-202X.2020.07.009
- Abstract:
- Abstract: Objective To discuss the dosimetric differences in hypofractionated radiotherapy plans for breast cancer optimized by physical functions versus biological functions. Methods Fifteen left-sided breast cancer patients underwent radiotherapy were enrolled in the study. The volumetric modulated arc therapy plans of the patients were respectively designed with physical functions (DV group), biological-physical functions (DV+EUD group and EUD+DV group) and biological functions (EUD group). The dosimetric differences among 4 optimization methods in the hypofractionated radiotherapy for breast cancer were evaluated by calculating and analyzing dosimetric parameters. Results There were statistical differences between plans optimized by biological functions (EUD, EUD+DV, DV+EUD groups) and the plan only optimized by physical functions (DV group) (P<0.05). The dosimetric results of target areas in EUD group and EUD+DV group were similar, and the EUD and tumor control probability of target areas in the two groups were higher than those in DV group and DV+EUD group. Moreover, the dose of the ipsilateral lung in EUD group was less than that in the other 3 groups, and MU was 16% lower than DV group and DV+EUD group. Conclusion Biological functions not only have significant advantages in improving the EUD and tumor control probability of target areas and protecting the ipsilateral lung, but also improve treatment efficiency. Biological functions can be used to optimize the treatment plan for breast cancer.
Last Update: 2020-07-28