Correlation between 3D pCASL of nasopharyngeal carcinoma with Ki-67 index and its value in clinical staging(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2020年第2期
- Page:
- 190-194
- Research Field:
- 医学影像物理
- Publishing date:
Info
- Title:
- Correlation between 3D pCASL of nasopharyngeal carcinoma with Ki-67 index and its value in clinical staging
- Author(s):
- WU Wenxiu1; 2; 3; JIANG Guihua1; 2; XU Zhifeng3; PAN Aizhen3; GAO Mingyong3; ZHOU Xinhan3
- 1. the Second Clinical Medical College of Southern Medical University, Guangzhou 510282, China; 2. Department of Imaging, Guangdong Second Provincial General Hospital, Guangzhou 510317, China; 3. Department of Imaging, Foshan First People’s Hospital (Foshan Hospital Affiliated to Sun Yat-sen University), Foshan 528000, China
- Keywords:
- Keywords: nasopharyngeal carcinoma; magnetic resonance imaging; three-dimensional pseudo-continuous arterial spin labeling; Ki-67
- PACS:
- R739.62；R445.2
- DOI:
- DOI:10.3969/j.issn.1005-202X.2020.02.011
- Abstract:
- Abstract: Objective To explore the correlation between the parameters derived from three-dimensional pseudo-continuous arterial spin labeling (3D pCASL) of nasopharyngeal carcinoma (NPC) with Ki-67 index and discuss its value in clinical staging. Methods Forty-eight cases with an initial diagnosis of NPC confirmed by pathology were collected, among which 36 cases were assessed by immunohistochemistry with Ki-67 index. The patients were grouped into T, N and clinical stages and then divided into low- and high-grade groups. All patients were given magnetic resonance plain and enhanced nasopharyngeal scans and 3D-ASL sequence scan. The mean value (BFmean), minimum value (BFmin) and maximum value (BFmax) of blood flow in tumor parenchyma were measured, and the differences in the 3 quantitative parameters of ASL between high- and low-grade groups were compared with rank sum test. Finally, the correlations between 3 quantitative parameters and Ki-67 index were analyzed. Results BFmean, BFmax and BFmin in the high-grade groups of T, N and clinical stages were higher than those in the low-grade groups. Ki-67 index was significantly correlated with BFmax (r=0.408, P=0.014), with statistical significance (P<0.05). Conclusion As a non-invasive functional magnetic resonance perfusion imaging, 3D pCASL can be used to evaluate the blood perfusion of NPC. Moreover, BFmax can be used to assess the degree of NPC proliferation, which is helpful to evaluate the prognosis of NPC patients.
Last Update: 2020-03-03