Application of base dose plan compensation optimization method in intensity-modulated radiotherapy for lung cancer(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2020年第8期
- Page:
- 1000-1004
- Research Field:
- 医学放射物理
- Publishing date:
Info
- Title:
- Application of base dose plan compensation optimization method in intensity-modulated radiotherapy for lung cancer
- Author(s):
- PENG Qinghe1; 2; YE Zhifu3; WANG Zhiguang3; PENG Yinglin1
- 1. Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China 2. School of Biomedical Engineering, Southern Medical University, Guangzhou 510515, China 3. the First Affiliated Hospital of Guangxi University of Chinese Medicine, Nangning 530000, China
- Keywords:
- Keywords: lung cancer intensity-modulated radiotherapy dose compensation optimization base dose plan compensation hot and cold spot control
- PACS:
- R734.2；R815.6
- DOI:
- DOI:10.3969/j.issn.1005-202X.2020.08.012
- Abstract:
- Abstract: Objective To compare the dosimetric differences between base dose plan compensation (BDPC group) and hot and cold spot control (HCSC group) in intensity-modulated radiotherapy for lung cancer. Methods Thirteen patients with lung cancer were enrolled in the study. For each patient, BDPC plan and HCSC plan were designed with the same optimization criteria. The prescription dose were 60 Gy in 26 fractions delivered to PGTV and 50 Gy in 26 fractions delivered to PCTV. The parameters for the dose evaluation of target areas and organs-at-risk, planning time and monitor units were compared, and paired t-test or non-parametric test was used for statistical analysis. Results Compared with HCSC group, BDPC group had higher CI (PGTV: 0.66±0.14 vs 0.58±0.15, P<0.05 PCTV: 0.61±0.28 vs 0.57±0.27, P=0.066) and lower HI (PGTV: 0.08±0.02 vs 0.11±0.05, P<0.05 PCTV: 0.23±0.03 vs 0.27±0.03, P<0.05). BDPC group also had advantages in organs-at-risk sparing. The Dmax of esophagus as well as the V5 Gy and V20 Gy of both lungs in BDPC group were significantly lower than those in HCSC group ［(59.92 ±2.87) Gy vs (62.09 ±3.34) Gy, 49%±18% vs 51%±11 % and 22%±9% vs 24% ±7%, respectively all P<0.05］. Conclusion For intensity-modulated radiotherapy for lung cancer, the dose profile obtained by BDPC optimization method is superior to that obtained by HCSC optimization method. BDPC optimization method can not only ensure the target coverage, but also lower the irradiation doses to organs-at-risk, worthy of application and popularization in clinic.
Last Update: 2020-08-27