Abnormal resting-state functional connectivity of the dorsolateral prefrontal lobe in patients
with primary insomnia(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2020年第5期
- Page:
- 574-578
- Research Field:
- 医学影像物理
- Publishing date:
Info
- Title:
- Abnormal resting-state functional connectivity of the dorsolateral prefrontal lobe in patients
with primary insomnia
- Author(s):
- XIE Dongdong1; CHENG Yongxin1; WANG Xianfu1; LIU Chang1; CUI Yongting1; TIAN Shiyu1; LIU Bo2; YU Dahua1
- 1. School of Information Engineering, Inner Mongolia University of Science and Technology, Baotou 014010, China 2. The First
Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou 014010, China
- Keywords:
- primary insomnia dorsolateral prefrontal lobe resting-state functional connectivity
- PACS:
- R318；R749.99
- DOI:
- 10.3969/j.issn.1005-202X.2020.05.008
- Abstract:
- Objective: To explore the abnormal of functional connectivity (FC) of dorsolateral prefrontal lobe in patients with primary insomnia using FC analysis in resting-state functional magnetic resonance imaging ( fMRI). Method: Totally 33 primary insomnia patients and 33 age-, gender- and education -matched healthy control subjects underwent resting-state fMRI. The dorsolateral prefrontal lobe were selected as ROIs, and FC analysis with other voxels in the brain to obtain abnormal FC between the two groups. Then relationships between abnormal FC and clinical scale scores were investigated with Pearson’s correlation analysis. Result: Compared with the healthy control group, The FC between the left dorsolateral prefrontal lobe and the left inferior occipital gyrus, the right inferior occipital gyrus, the right middle occipital gyrus, the right temporal lobe, the right medial superior frontal gyrus and the right fusiform gyrus were enhanced, the functional connections with the left anterior cingulate cortex, the right parahippocampal gyrus, the right insula, the right dorsolateral superior frontal gyrus, the right superior parietal gyrus, the right postcentral gyrus and the right precentral gyrus were weakened in primary insomnia （p<0.05, number of voxel≥100, FDR correction）. And the FC values of left dorsolateral prefrontal lobe and left inferior occipi tal lobe were positively correlated with SRSS scores（p=0.035）. conclusion: FC is abnormal between the dorsolateral prefrontal lobe and multiple brain regions in primary insomnia patients, it may provide some new imaging evidence for understanding the neurological mechanism of primary insomnia ．
Last Update: 2020-06-03