Low-intensity pulsed electromagnetic fields accelerates skin wound healing in type 2 diabetic mice: an experimental research(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2020年第7期
- Page:
- 912-917
- Research Field:
- 医学生物物理
- Publishing date:
Info
- Title:
- Low-intensity pulsed electromagnetic fields accelerates skin wound healing in type 2 diabetic mice: an experimental research
- Author(s):
- HUO Bo1; DING Yuanjun2; CAI Jing2; ZHANG Meixia3
- 1. Department of Respiratory Medicine, the First Affiliated Hospital of Air Force Medical University of PLA, Xian 710032, China 2. Department of Military Biomedical Engineering, Air Force Medical University of PLA, Xian 710032, China 3. Nursing Department, the First Affiliated Hospital of Air Force Medical University of PLA, Xian 710032, China
- Keywords:
- Keywords: type 2 diabetes mellitus soft tissue wound low-intensity pulsed electromagnetic field inflammatory cytokines tensile strength
- PACS:
- R318；Q64
- DOI:
- DOI:10.3969/j.issn.1005-202X.2020.07.022
- Abstract:
- Abstract: Objective To identify the therapeutic effects of low-intensity pulsed electromagnetic fields (PEMF) on the soft tissue wound healing in type 2 diabetic mice. Methods Thirty-two 3-month-old male type 2 diabetic db/db mice and 16 wild type control mice with the same background were assigned to db/db group (db/db) and db/db treated with PEMF group (db/db+PEMF) and wild type group (Wild type), with 16 mice in each group. Four mice in each group were sacrificed on day 5, 12 and 19 after the wound model establishment. The induction of dorsal wound model was performed on all mice. The mice in db/db+PEMF group were subjected to whole-body PEMF stimulation for 2 h per day. The therapeutic effects were evaluated by wound healing rate, wound tensile strength, wound tissue histopathology and ELISA assay. Results PEMF stimulation significantly increased the wound healing rate in db/db mice on the 5th, 12nd and 19th day postoperatively (P<0.05), and also decreased the overall wound healing period in db/db mice (P<0.05). Moreover, PEMF simulation increased wound tensile strength on the 5th, 12nd and 19th day postoperatively (P<0.05), and also decreased the number of inflammatory cells in wound tissues, suppressed the expressions of inflammatory cytokines IL-1β and TNF-α (P<0.05), increased the expressions of VEGF and IGF-1 (P<0.05). Conclusion Low-intensity PEMF stimulation is capable of significantly accelerating soft tissue healing in type 2 diabetic db/db mice, which may be related to its anti-inflammatory response and promotion of collagen deposition and vascular regeneration.
Last Update: 2020-07-28