Abstract

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Title:: Mechanism of hemolysis in an interventional micro-axial flow blood pump and analysis of its influencing factors

Author(s):: TANG Jie1; CHENG Yunzhang1; ZHENG Qiwen2; ZHANG Wenjing1; 1.School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China; 2. ForQaly Medical (Shanghai) Company Limited, Shanghai 201138, China

Abstract:: Abstract: Hemolytic property is one of the important evaluation factors to determine whether the blood pump is reliable, and it is also a major challenge in the development of blood pumps. Based on the structural characteristics of an interventional micro-axial blood flow pump, the mechanism of hemolysis and major influencing factors of the micro-axial blood flow pump are summarized. Firstly, the structural characteristics of the interventional micro-axial flow blood pump are introduced, such as small volume, high rotation speed, and small clearance between the impeller rim and the pump casing, and then the mechanism of hemolysis is discussed from two aspects of shear-induced hemolysis and cavitation-induced hemolysis. Finally, the main mechanical factors, namely shear force and negative pressure, which lead to mechanical hemolysis of the interventional micro-axial flow blood pump, are analyzed. Excessive shear force in the pump or excessively long action time may cause erythrocyte to be damaged and lead to hemolysis, while negative pressure may lead to blood pump cavitation and cause damages to the blood. In conclusion, improper structure design of the blood pump results in hemolysis due to the high shear stress and local negative pressure during mechanical movement and turbulent motion. Therefore, the effects of various factors on the hemolysis in blood pump should be fully considered in the design stage.