Abstract

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Title:: Design and verification of a new compact dose delivery system for proton therapy

Author(s):: CHANG Cheng; WANG Ruoxi; DU Yi; YUE Haizhen; WU Hao; ZHANG Yibao; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China

Keywords:: Keywords: laser-plasma acceleration; proton therapy; nozzle system; contoured scatter; Monte Carlo simulation

Abstract:: Abstract: Objective In view of the characteristics of proton beams after laser-plasma acceleration, to design a new type of compact nozzle system for dose delivery, and verify the applicability and efficiency of the proposed method by numerical simulation. Methods Based on the proton beam properties achieved in the laser-plasma acceleration, a contoured scatter was designed with the common software NEU (Nozzle with Everything Upstream). With proper selection of the divergence angle and the energy spread of the proton beams, the efficiency of dose delivery was further improved. After the dose delivery with the proposed method, the dose distribution of a water phantom was analyzed and verified with TOPAS (TOol for PArticle Simulation)/Geant4 (GEometry ANd Tracking). Results The flatness of the depth dose distribution in a cylindrical target area with a diameter of 6 cm and a height of 5 cm was within ±1%, and the lateral flatness was within ±3%. Conclusion The proposed compact nozzle system and dose delivery method are applicable to the characteristics of the laser-driven proton beam. The dose in the target areas of water phantom is able to be delivered uniformly, efficiently and robustly.