Effects of ovaries sparing on planning target volume and organs-at-risk during linear
accelerator radiotherapy for cervical cancer(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2020年第9期
- Page:
- 1115-1119
- Research Field:
- 医学人工智能
- Publishing date:
Info
- Title:
- Effects of ovaries sparing on planning target volume and organs-at-risk during linear
accelerator radiotherapy for cervical cancer
- Author(s):
- HUANG Yangyang1; LI Jiabing1; TIAN Yulong2; DONG Shengnan3; YANG Jun1
- 1. Department of Radiation Oncology, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450014, China 2.
Department of Radiation Oncology, the Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China 3. Institute of
Nuclear Science and Technology, University of South China, Hengyang 421001, China
- Keywords:
- cervical cancer ovaries sparing radiotherapy dosimetric difference
- PACS:
- R735.1；R811.1
- DOI:
- 10.3969/j.issn.1005-202X.2020.09.007
- Abstract:
- Objective To explore the dosimetric effects of ovaries sparing in linear accelerator (LA) radiotherapy for cervical
cancer on planning target volume (PTV) and organs-at-risk (OAR). Methods Sixteen patients treated with ovaries-sparing LA
radiotherapy for cervical cancer were randomly selected, and 7-field IMRT plans were designed for each patient based on
XiO treatment planning system. The 95% of PTV receiving 45 Gy irradiation dose was achieved by normalization. With the
same optimization parameters except the treatment of ovaries, two groups of treatment plans, namely ovaries-sparing group
and no ovaries-sparing group, were generated, and the dosimetric differences of PTV and OAR between two groups were
compared. Results Both groups met the clinical requirements. The conformity index (CI) in ovaries-sparing group was
significantly lower than that in no ovaries-sparing group (0.708±0.051 vs 0.808±0.056, P<0.05), and the homogeneity index
(HI) in ovaries-sparing group was much higher (0.135±0.023 vs 0.087±0.012, P<0.05). For OAR, the Dmax of small intestine,
bladder, rectum and left femoral head in ovaries-sparing group was higher than that in no ovaries-sparing group (P<0.05), but
there was no significant difference in Dmean, V45, V40, V30, V20 and V10 (P>0.05), and the Dmean and Dmax of spinal cord were
similar in two groups, without statistical differences (P>0.05). Conclusion Ovaries sparing significantly affects the dose
distribution in PTV, but has trivial dosimetric effects on OAR.
Last Update: 2020-09-25