Abstract

Info

Title:: Detection of prostate cancer based on terahertz spectroscopy and imaging

Author(s):: ZHANG Junxi1; LIU Zhenxiang1; ZHANG Ping2; BAI Zhiming1; 1. Department of Urinary Surgery, Central South University Xiangya School of Medicine Affiliated Haikou Hospital, Haikou 570208, China; 2. School of Mechanical Engineering and Automation, Fuzhou University, Fuzhou 350108, China

Keywords:: ; Keywords: prostate cancer; terahertz spectrum and imaging; H-E staining; absorption coefficient; refractive index

Abstract:: Abstract: Objective To investigate the application of terahertz electromagnetic waves in the diagnosis of prostate cancer. Methods The paraffin tissue mass of 32 patients with prostate cancers were extracted and detected with H-E staining and terahertz reflection imaging. According to the H-E pathological results, the tumor area, normal prostate tissue area and smooth muscle area of the prostate tissue sample were identified, and then terahertz transmission spectral detection was performed on the 3 areas. Results There were correlations in the shape and size of the tumor areas identified by reflection imaging recognition and H-E staining (P<0.001). Significant differences were found in the absorption coefficient and refractive index measured by transmission spectra in the 3 areas (P<0.001). The absorption coefficient of terahertz spectrum was correlated with the percentage of nucleus (P<0.001). Moreover, there were differences in the absorption coefficient among the 5 groups of different tumor grades and groupings (P<0.001). Conclusion Terahertz imaging can clearly identify the contour of paraffin-embedded prostate tumor. Terahertz spectroscopy can not only distinguish smooth muscle, tumor and normal prostate tissue, but also identify prostate cancer of different grades and groupings. The optical reaction of tumor paraffin tissue to terahertz is related to the percentage of nucleus.